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In 24 hours after a single administration of melleril (30 mg/kg) an elevated injuriousness of "heavy" and "light" liver lysosomes of rats subjected to "in vitro" treatment with a pH 5.0 solution at 37 degrees was recorded. Introduction of melleril to rats with toxic CCl4-induced hepatitis (CCl4 dosage of 0.15 ml per 100 g body weight) depresses free activity of acid phosphatase, this fall, however, failing to reach the corresponding values in intact animals. An elevated injuriousness of "heavy" and "light" lysosomas undergoing treatment at pH 5.0 and 37degrees, revealed in all variants of the tests, is related to activation of lysosomal phospholipases with subsequent liberation of surfactant lipids and volumetric changes of the particles.
T A Korolenko, and
E I Tsilli, and
T V Rusova
January 1975,
Biulleten' eksperimental'noi biologii i meditsiny,
T A Korolenko, and
E I Tsilli, and
T V Rusova
December 1974,
Bulletin of experimental biology and medicine,
T A Korolenko, and
E I Tsilli, and
T V Rusova
January 1974,
Farmakologiia i toksikologiia,
T A Korolenko, and
E I Tsilli, and
T V Rusova
September 1980,
Gigiena i sanitariia,
T A Korolenko, and
E I Tsilli, and
T V Rusova
January 2003,
Bulletin of experimental biology and medicine,
T A Korolenko, and
E I Tsilli, and
T V Rusova
August 1975,
Biulleten' eksperimental'noi biologii i meditsiny,
T A Korolenko, and
E I Tsilli, and
T V Rusova
October 2012,
Bulletin of experimental biology and medicine,
T A Korolenko, and
E I Tsilli, and
T V Rusova
January 1999,
Eksperimental'naia i klinicheskaia farmakologiia,
T A Korolenko, and
E I Tsilli, and
T V Rusova
September 1984,
Biulleten' eksperimental'noi biologii i meditsiny,
T A Korolenko, and
E I Tsilli, and
T V Rusova
August 2012,
Bulletin of experimental biology and medicine,
