Biomaterial Database

[Comparative physiological effects of partially hydrogenated herring and rapeseed oils in the rat. 1. Mean-term effects on growth, organ weights and heart histology]. 1976

P O Astorg, and R Cluzan

Two partially hydrogenated herring oils, containing 15% or 30% of C 22: 1, supplemented or not with linoleic (maize oil), have been fed for 16 weeks to growing rats (15% by weight in the diet), and their effects have been compared to those of peanut oil (controls), and to those of 2 mixtures of rapeseed oil and peanut oil having similar C 22:1 contents (15% and 30%). On the basis of equal amounts of ingested food, the growth of the rats is lower with herring and rapeseed oil than with peanut oil; this phenomenon is emphasized in the case of the non--C 18:2--supplemented herring oils. Herring and rapeseed oils induce an increase of liver particularly with the one having the highest content of trans fatty acids. Heart lesions have been observed in rats feed herring or rapeseed oils, not in the control group. The frequency of these lesions is greater with rapeseed oil (11/13) than with herring oils (11/24). This result suggests that erucic acid (cis delta 13 docosenoic acid) is more pathogenic than at least some of its isomers present in the hydrogenated herring oils (particularly the trans isomers). In the second part of this paper, we report the effects of the tested dietary fats on organ lipids after very short-term (3-7 days) or mean-term (16 weeks) experiments.

UI	MeSH Term	Description	Entries
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008297	Male		Males
D009206	Myocardium	The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.	Muscle, Cardiac,Muscle, Heart,Cardiac Muscle,Myocardia,Cardiac Muscles,Heart Muscle,Heart Muscles,Muscles, Cardiac,Muscles, Heart
D009821	Oils	Unctuous combustible substances that are liquid or easily liquefiable on warming, and are soluble in ether but insoluble in water. Such substances, depending on their origin, are classified as animal, mineral, or vegetable oils. Depending on their behavior on heating, they are volatile or fixed. (Dorland, 28th ed)
D009929	Organ Size	The measurement of an organ in volume, mass, or heaviness.	Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D010367	Arachis	A plant genus of the family FABACEAE that includes peanuts.	Arachis hypogaea,Peanuts,Peanut
D001835	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	Body Weights,Weight, Body,Weights, Body
D004041	Dietary Fats	Fats present in food, especially in animal products such as meat, meat products, butter, ghee. They are present in lower amounts in nuts, seeds, and avocados.	Fats, Dietary,Dietary Fat,Fat, Dietary
D005399	Fishes	A group of cold-blooded, aquatic vertebrates having gills, fins, a cartilaginous or bony endoskeleton, and elongated bodies covered with scales.