Biomaterial Database

The lymphocytic absorption of p,p'-DDT and some structurally-related compounds in the rat. 1976

S M Sieber

The lymphatic absorption of a series of 14C-labelled compounds structurally related to p,p'-DDT has been examined in thoracic duct-cannulated rats. The compounds (p,p'-DDT, p,p-DDT, P,P'-DDD, p,p-DDD, DDE, DDA and 2,4-D) varied markedly in lipid solubility, as well as in extent of lymphatic absorption, urinary and biliary excretion, and localization in body fat. More than 12% of the dose was recovered in 24-hour thoracic duct lymph of rats treated with the p,p'- and o,p-isomers of DDT and DDD and with DDE, and this percentage was increased by concomitant fat absorption. A strict parallel between lipid solubility and lymphatic absorption was not observed in this series of compounds, possibly because of differences in their rates and routes of excretion.

UI	MeSH Term	Description	Entries
D007422	Intestines	The section of the alimentary canal from the STOMACH to the ANAL CANAL. It includes the LARGE INTESTINE and SMALL INTESTINE.	Intestine
D008196	Lymph	The interstitial fluid that is in the LYMPHATIC SYSTEM.	Lymphs
D008297	Male		Males
D008939	Mitotane	A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.	o,p-DDD,ortho,para-DDD,Chloditan,Chlodithane,Khloditan,Lysodren,Mytotan,ortho,para DDD
D003632	Dichlorodiphenyldichloroethane	An organochlorine insecticide that is slightly irritating to the skin. (From Merck Index, 11th ed, p482)	DDD,TDE
D003633	Dichlorodiphenyl Dichloroethylene	An organochlorine pesticide, it is the ethylene metabolite of DDT.	DDE,DDX,1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene,DDMU,p,p'-DDE,p,p-Dichlorodiphenyldichloroethylene,Dichloroethylene, Dichlorodiphenyl
D003634	DDT	A polychlorinated pesticide that is resistant to destruction by light and oxidation. Its unusual stability has resulted in difficulties in residue removal from water, soil, and foodstuffs. This substance may reasonably be anticipated to be a carcinogen: Fourth Annual Report on Carcinogens (NTP-85-002, 1985). (From Merck Index, 11th ed)	1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane,4,4'-DDT,4,4'-Dichlorodiphenyltrichloroethane,Benzochloryl,Chlorophenothane,TbisC-ethane,p',p'-DDT,4,4' DDT,4,4' Dichlorodiphenyltrichloroethane,TbisC ethane
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001646	Bile	An emulsifying agent produced in the LIVER and secreted into the DUODENUM. Its composition includes BILE ACIDS AND SALTS; CHOLESTEROL; and ELECTROLYTES. It aids DIGESTION of fats in the duodenum.	Biliary Sludge,Sludge, Biliary
D012996	Solutions	The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)	Solution