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In order to evaluate the relation of cardiac norepinephrine (NE) release to left ventricular function, blood was taken simultaneously from the coronary sinus (CS) and the aorta (A) in 19 patients with heart diseases, at rest and during isometric handgrip exercise (IHG) at 30% of their maximal contraction. Plasma NE was analyzed by Renzini's THI method. The concentrations of plasma NE at rest were 397 +/- 66 (S.E.M.) ng/liter in CS and 292 +/- 50 in A. IHG significantly increased NE to 578 +/- 88 in CS and to 462 +/- 85 in A (p less than 0.001). Estimated NE release from the heart (deltaNE = NECS - NEA) correlated inversely to left ventricular end-diastolic pressure at rest (r = -0.520, p less than 0.05) and during IHG (r= -0.689, p less than 0.01). The changes in deltaNE induced by IHG correlated to the slope of the left ventricular function curve (r=0.618, p less than 0.01). It is concluded that the response of cardiac NE release to exercise is reduced in patients with depressed cardiac function.
T Haneda, and
Y Miura, and
K Miyazawa, and
T Sato, and
K Shirato, and
T Honna, and
T Nakajima, and
T Arai, and
K Kobayashi, and
H Sakuma, and
K Yoshinaga, and
T Takishima
June 1972,
British heart journal,
T Haneda, and
Y Miura, and
K Miyazawa, and
T Sato, and
K Shirato, and
T Honna, and
T Nakajima, and
T Arai, and
K Kobayashi, and
H Sakuma, and
K Yoshinaga, and
T Takishima
January 1981,
Bollettino della Societa italiana di cardiologia,
T Haneda, and
Y Miura, and
K Miyazawa, and
T Sato, and
K Shirato, and
T Honna, and
T Nakajima, and
T Arai, and
K Kobayashi, and
H Sakuma, and
K Yoshinaga, and
T Takishima
January 1978,
Giornale italiano di cardiologia,
T Haneda, and
Y Miura, and
K Miyazawa, and
T Sato, and
K Shirato, and
T Honna, and
T Nakajima, and
T Arai, and
K Kobayashi, and
H Sakuma, and
K Yoshinaga, and
T Takishima
March 2001,
American journal of physiology. Heart and circulatory physiology,
T Haneda, and
Y Miura, and
K Miyazawa, and
T Sato, and
K Shirato, and
T Honna, and
T Nakajima, and
T Arai, and
K Kobayashi, and
H Sakuma, and
K Yoshinaga, and
T Takishima
June 1981,
Circulation research,
T Haneda, and
Y Miura, and
K Miyazawa, and
T Sato, and
K Shirato, and
T Honna, and
T Nakajima, and
T Arai, and
K Kobayashi, and
H Sakuma, and
K Yoshinaga, and
T Takishima
July 2023,
Cureus,
T Haneda, and
Y Miura, and
K Miyazawa, and
T Sato, and
K Shirato, and
T Honna, and
T Nakajima, and
T Arai, and
K Kobayashi, and
H Sakuma, and
K Yoshinaga, and
T Takishima
April 1973,
British heart journal,
T Haneda, and
Y Miura, and
K Miyazawa, and
T Sato, and
K Shirato, and
T Honna, and
T Nakajima, and
T Arai, and
K Kobayashi, and
H Sakuma, and
K Yoshinaga, and
T Takishima
April 2021,
Kardiologia polska,
T Haneda, and
Y Miura, and
K Miyazawa, and
T Sato, and
K Shirato, and
T Honna, and
T Nakajima, and
T Arai, and
K Kobayashi, and
H Sakuma, and
K Yoshinaga, and
T Takishima
March 2021,
Medicine and science in sports and exercise,
T Haneda, and
Y Miura, and
K Miyazawa, and
T Sato, and
K Shirato, and
T Honna, and
T Nakajima, and
T Arai, and
K Kobayashi, and
H Sakuma, and
K Yoshinaga, and
T Takishima
January 2014,
American journal of physiology. Heart and circulatory physiology,
