Biomaterial Database

Relationship between electroacupuncture analgesia and dopamine receptors in nucleus accumbens. 1997

Y Q Wang, and X D Cao, and K Y Li, and G C Wu

Department of Neurobiology, Shanghai Medical University, China.

OBJECTIVE To study the roles of dopamine (DA) D1 and D2 receptors in nucleus accumbens in electroacupuncture analgesia (EAA) and the potentiation of EAA of rats induced by l-tetrahydropalmatine (l-THP), a dopamine receptor antagonist. METHODS SK&F-38393 and quinpirole hydrochloride (Qui), highly selective agonists of D1 and D2 receptors, respectively were injected into nucleus accumbens of rats. RESULTS SK&F-38393 (5 and 10 micrograms) attenuated the potentiation of EAA induced by l-THP, 10 micrograms SKF38393 attenuated EAA as well, while Qui (10 and 20 micrograms) had no effect on EAA and the potentiation of EAA induced by l-THP. CONCLUSIONS D1 but not D2 receptor in nucleus accumbens play an important role in EAA and the potentiation of EAA induced by l-THP.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009714	Nucleus Accumbens	Collection of pleomorphic cells in the caudal part of the anterior horn of the LATERAL VENTRICLE, in the region of the OLFACTORY TUBERCLE, lying between the head of the CAUDATE NUCLEUS and the ANTERIOR PERFORATED SUBSTANCE. It is part of the so-called VENTRAL STRIATUM, a composite structure considered part of the BASAL GANGLIA.	Accumbens Nucleus,Nucleus Accumbens Septi,Accumbens Septi, Nucleus,Accumbens Septus, Nucleus,Accumbens, Nucleus,Nucleus Accumbens Septus,Nucleus, Accumbens,Septi, Nucleus Accumbens,Septus, Nucleus Accumbens
D011954	Receptors, Dopamine	Cell-surface proteins that bind dopamine with high affinity and trigger intracellular changes influencing the behavior of cells.	Dopamine Receptors,Dopamine Receptor,Receptor, Dopamine
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001600	Berberine Alkaloids	A group of related plant alkaloids that contain the BERBERINE heterocyclic ring structure.	Berbines,Alkaloids, Berberine
D015647	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	A selective D1 dopamine receptor agonist used primarily as a research tool.	1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-1-phenyl-,R-SK&F 38393,SK&F-38393,SKF 38393-A,SKF-38393,SKF38393,RSK&F 38393,SK&F 38393,SK&F38393,SKF 38393,SKF 38393 A,SKF 38393A
D015667	Acupuncture Analgesia	Analgesia produced by the insertion of ACUPUNCTURE needles at certain ACUPUNCTURE POINTS on the body. This activates small myelinated nerve fibers in the muscle which transmit impulses to the spinal cord and then activate three centers - the spinal cord, midbrain and pituitary/hypothalamus - to produce analgesia.	Analgesia, Acupuncture,Acupuncture Anesthesia,Anesthesia, Acupuncture
D015671	Electroacupuncture	A form of acupuncture with electrical impulses passing through the needles to stimulate NERVE TISSUE. It can be used for ANALGESIA; ANESTHESIA; REHABILITATION; and treatment for diseases.
D017207	Rats, Sprague-Dawley	A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.	Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats