-transparent.png){kind=logo}
OBJECTIVE To evaluate the effect of brucine (Bru) i.p. at analgesic doses on the nonspecific immune responses in normal and cyclophosphamide (Cyc)-treated mice. METHODS The clearance of charcoal particles, the immune organ weights, the white blood cell counts in peripheral blood, the phagocytosis to neutral red (NR) of PMO and its IL-1 production in vitro were tested. RESULTS In normal mice, Bru slightly enhanced the clearance of charcoal particles, the phagocytosis of PMO, IL-1 production, the immune organ weights and the WBC counts (P > 0.05), whereas in Cyc-induced subnormal immunity model mice, Bru greatly enhanced these nonspecific immune responses (P < 0.05 or P < 0.01). The effects of Bru were most marked i.p. at 10 mg.kg-1 in vivo or 0.1-10 mg.L-1 in vitro. CONCLUSIONS Bru i.p. at an analgesic dosage has dose- and function-dependent immunoregulatory effects.
H W Zhao, and
Y H Li, and
Y N Zhu, and
S A Weng, and
Y Zhang, and
S W Ge
January 1992,
American journal of reproductive immunology (New York, N.Y. : 1989),
H W Zhao, and
Y H Li, and
Y N Zhu, and
S A Weng, and
Y Zhang, and
S W Ge
May 1983,
The American journal of clinical nutrition,
H W Zhao, and
Y H Li, and
Y N Zhu, and
S A Weng, and
Y Zhang, and
S W Ge
January 1979,
Annals of the New York Academy of Sciences,
H W Zhao, and
Y H Li, and
Y N Zhu, and
S A Weng, and
Y Zhang, and
S W Ge
May 2023,
Journal of clinical medicine,
H W Zhao, and
Y H Li, and
Y N Zhu, and
S A Weng, and
Y Zhang, and
S W Ge
March 1981,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
H W Zhao, and
Y H Li, and
Y N Zhu, and
S A Weng, and
Y Zhang, and
S W Ge
January 1991,
Progress in clinical and biological research,
H W Zhao, and
Y H Li, and
Y N Zhu, and
S A Weng, and
Y Zhang, and
S W Ge
April 2012,
Immunopharmacology and immunotoxicology,
H W Zhao, and
Y H Li, and
Y N Zhu, and
S A Weng, and
Y Zhang, and
S W Ge
June 1972,
Surgery,
H W Zhao, and
Y H Li, and
Y N Zhu, and
S A Weng, and
Y Zhang, and
S W Ge
January 1976,
Radiology,
H W Zhao, and
Y H Li, and
Y N Zhu, and
S A Weng, and
Y Zhang, and
S W Ge
May 1987,
Israel journal of medical sciences,
