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Synthesis and antibacterial activity of 1 beta-methylcarbapenem having a 1,3-diazabicyclo[3.3.0]octan-4-one moiety, Part II. 1999
C H Oh, and
S C Lee, and
S J Park, and
I K Lee, and
K H Nam, and
K S Lee, and
B Y Chung, and
J H Cho
Medicinal Chemistry Research Center, Korea Institute of Science and Technology, Seoul, Korea.
The synthesis of a new series of 1 beta-methylcarbapenems having a 1,3-diazabicyclo[3.3.0]octan-4-one moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria are tested and the effect of substituent on the bicyclic ring was investigated. A particular compound (11 h) having aminoethyl group showed the most potent antibacterial activity.
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