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The inhibitory effect of somatostatin on the secretion of glucagon permits the examination of the effect of glucagon on some metabolic parameters in the insulin-dependent diabetic patient. The results obtained in 5 insulin-dependent diabetics and in 4 pancreatectomized patients revealed an inhibitory effect of somatostatin on blood glucose in the juvenile-type diabetics, but failed to show this influence of somatostatin in the pancreatectomized patients. These observations indicate a participation of glucagon in the generation of hyperglycaemia in diabetes mellitus. However, the failure of somatostatin to influence the blood glucose level in pancreatectomized patients contrasts with the results obtained in dogs and emphasizes the difficulty and pit falls in the application of animal experiments with somatostatin to humans.
K H Tragl, and
H Pointner, and
H Kinast, and
U Flegel, and
E Deutsch
January 1978,
Nihon Naibunpi Gakkai zasshi,
K H Tragl, and
H Pointner, and
H Kinast, and
U Flegel, and
E Deutsch
January 1978,
Pathologie-biologie,
K H Tragl, and
H Pointner, and
H Kinast, and
U Flegel, and
E Deutsch
January 1978,
La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris,
K H Tragl, and
H Pointner, and
H Kinast, and
U Flegel, and
E Deutsch
June 1980,
Deutsche medizinische Wochenschrift (1946),
K H Tragl, and
H Pointner, and
H Kinast, and
U Flegel, and
E Deutsch
February 1982,
Geburtshilfe und Frauenheilkunde,
K H Tragl, and
H Pointner, and
H Kinast, and
U Flegel, and
E Deutsch
December 1981,
Deutsche medizinische Wochenschrift (1946),
K H Tragl, and
H Pointner, and
H Kinast, and
U Flegel, and
E Deutsch
September 1981,
Revista medica de Chile,
K H Tragl, and
H Pointner, and
H Kinast, and
U Flegel, and
E Deutsch
October 1976,
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
K H Tragl, and
H Pointner, and
H Kinast, and
U Flegel, and
E Deutsch
January 1982,
Revue francaise des maladies respiratoires,
K H Tragl, and
H Pointner, and
H Kinast, and
U Flegel, and
E Deutsch
June 1979,
Revista espanola de fisiologia,
