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Previous studies of patients with lymphoid malignancies have suggested a relationship between survival and the presence of more than 40% hard-mirror cells in the bone marrow. This report represents the first detailed study of a patient with American Burkitt's lymphoma with numerous hand-mirror cells in the bone marrow during the course of the disease. The Burkitt cells were atypical because of their hand-mirror configuration in the bone marrow, the presence of cytoplasmic glycogen, the finding of an IgG surface marker, and a strongly positive acid phosphatase staining reaction. The presence of increased numbers of hand-mirror forms in the bone marrow during the course of the patient's illness may have clinical significance, because they were replaced by non-hand-mirror Burkitt cells in the terminal phase. More reports and investigations of patients with large numbers of hand-mirror forms in the bone marrow are needed to elucidate the full significance of this unusual cellular phenomenon.
H R Schumacher, and
T Rainey, and
L Davidson, and
D Simon, and
M Strong, and
W J Creegan, and
M L Holloway, and
S A Stass
October 1979,
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H R Schumacher, and
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M Strong, and
W J Creegan, and
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S A Stass
May 1982,
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H R Schumacher, and
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S A Stass
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Sangre,
H R Schumacher, and
T Rainey, and
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D Simon, and
M Strong, and
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M L Holloway, and
S A Stass
January 1978,
American journal of hematology,
H R Schumacher, and
T Rainey, and
L Davidson, and
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February 1981,
Cancer,
H R Schumacher, and
T Rainey, and
L Davidson, and
D Simon, and
M Strong, and
W J Creegan, and
M L Holloway, and
S A Stass
September 1977,
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H R Schumacher, and
T Rainey, and
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M Strong, and
W J Creegan, and
M L Holloway, and
S A Stass
May 1974,
Cancer research,
H R Schumacher, and
T Rainey, and
L Davidson, and
D Simon, and
M Strong, and
W J Creegan, and
M L Holloway, and
S A Stass
March 1970,
Cancer,
H R Schumacher, and
T Rainey, and
L Davidson, and
D Simon, and
M Strong, and
W J Creegan, and
M L Holloway, and
S A Stass
November 1986,
Archives of internal medicine,
H R Schumacher, and
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S A Stass
January 1985,
IARC scientific publications,
