[Systolic time intervals in obstructive hypertrophic cardiomyopathy. The effects of adrenergic beta-stimulation and beta-blockade in 38 cases (author's transl)]. 1976

E Giovannini, and O Ferrari, and F Pace, and F Milazzotto, and V Masini

The authors report on the behaviour of systolic time intervals, studied with a noninvasive poligraphic technique, under normal conditions, after adrenergic beta stimuls (orciprenaline) and successive beta blocker (pindolole) in 38 patients with obstructive cardiomyopathy. Under normal conditions, the authors observed a marked dispersion of PEP and TEVS data, which have, however, average normal values. The IPEP was reduced in 29% of cases, was normal in 47.3% and raised in 23.7%; the ITEVS was reduced in 55.2% of cases, was normal in 21.1%, raised in 23.7%; the PEP/TEVS was reduced in 23.7%, normal in 31.6% and raised in 44.7%. The beta stimulation demonstrated a number of behaviour patterns: the most frequent cause was a reduction of PEP in the cases where it had been raised or where it had remained within normal limits, an increase of TEVS in the cases where it had been diminished or normal, a reduction of the PEP/TEVS correlation where these values were increased or normal. The beta blocker, followed by beta stimulus, brought on variations opposite from those of the beta stimulation. Thus, one can consider the hypothesis that the possible behaviour patterns and combination of PEP and TEVS result from different anatomical and functional expressions that can become obstructive cardiomyopathy, according to the seriousness of the obstruction, the ventricular compliance and the contractility.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009200 Myocardial Contraction Contractile activity of the MYOCARDIUM. Heart Contractility,Inotropism, Cardiac,Cardiac Inotropism,Cardiac Inotropisms,Contractilities, Heart,Contractility, Heart,Contraction, Myocardial,Contractions, Myocardial,Heart Contractilities,Inotropisms, Cardiac,Myocardial Contractions
D009921 Metaproterenol A beta-2 adrenergic agonist used in the treatment of ASTHMA and BRONCHIAL SPASM. Orciprenaline,Alotec,Alupent,Astmopent,Metaprel,Metaproterenol Polistirex,Metaproterenol Sulfate,Orciprenaline Sulfate,Polistirex, Metaproterenol
D010869 Pindolol A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638) Prindolol,LB-46,Visken,LB 46,LB46
D002312 Cardiomyopathy, Hypertrophic A form of CARDIAC MUSCLE disease, characterized by left and/or right ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR; HYPERTROPHY, RIGHT VENTRICULAR), frequent asymmetrical involvement of the HEART SEPTUM, and normal or reduced left ventricular volume. Risk factors include HYPERTENSION; AORTIC STENOSIS; and gene MUTATION; (FAMILIAL HYPERTROPHIC CARDIOMYOPATHY). Cardiomyopathy, Hypertrophic Obstructive,Cardiomyopathies, Hypertrophic,Cardiomyopathies, Hypertrophic Obstructive,Hypertrophic Cardiomyopathies,Hypertrophic Cardiomyopathy,Hypertrophic Obstructive Cardiomyopathies,Hypertrophic Obstructive Cardiomyopathy,Obstructive Cardiomyopathies, Hypertrophic,Obstructive Cardiomyopathy, Hypertrophic
D005260 Female Females
D006321 Heart The hollow, muscular organ that maintains the circulation of the blood. Hearts
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

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