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The aim of this study was to investigate whether EEG source localization in the frequency domain, using the FFT dipole approximation (Lehmann, D. and Michel, C.M. Electroenceph. clin. Neurophysiol., 1990, 76: 271-276), would be useful for quantifying the frequency content of epileptic seizure activity. Between one and 7 extracranially recorded seizures were analyzed in each of 7 patients with mesolimbic epilepsy, who were seizure-free after temporal lobe resection. The full scalp frequency spectrum for the first 4 s after seizure onset, as well as for subsequent periods, was determined. Power peaks in the spectra were identified, and an instant dipole fit was performed for the frequencies corresponding to these peaks. Ictal frequencies, ranging between 3.5 and 8.5 Hz, showed a variable degree of stability over time in the different patients. For a particular frequency, dipole results were similar during the different phases of seizure development. In patients with more than one prominent frequency, dipole results for the different frequencies were similar. Dipole results were also similar between patients. We conclude that dipole localization of dominant frequencies, as obtained from full scalp FFT analysis, gives quite reproducible results for seizures originating in the mesial temporal area. The method may become a useful tool for the pre-surgical identification of patients with mesolimbic epilepsy.
G Lantz, and
C M Michel, and
M Seeck, and
O Blanke, and
T Landis, and
I Rosén
February 2000,
Psychiatry and clinical neurosciences,
G Lantz, and
C M Michel, and
M Seeck, and
O Blanke, and
T Landis, and
I Rosén
April 2009,
Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society,
G Lantz, and
C M Michel, and
M Seeck, and
O Blanke, and
T Landis, and
I Rosén
May 1995,
Neurology,
G Lantz, and
C M Michel, and
M Seeck, and
O Blanke, and
T Landis, and
I Rosén
January 2002,
Clinical EEG (electroencephalography),
G Lantz, and
C M Michel, and
M Seeck, and
O Blanke, and
T Landis, and
I Rosén
December 2013,
Epileptic disorders : international epilepsy journal with videotape,
G Lantz, and
C M Michel, and
M Seeck, and
O Blanke, and
T Landis, and
I Rosén
January 1994,
Epilepsia,
G Lantz, and
C M Michel, and
M Seeck, and
O Blanke, and
T Landis, and
I Rosén
February 1998,
Epilepsia,
G Lantz, and
C M Michel, and
M Seeck, and
O Blanke, and
T Landis, and
I Rosén
April 2002,
Seizure,
G Lantz, and
C M Michel, and
M Seeck, and
O Blanke, and
T Landis, and
I Rosén
January 2008,
Clinical EEG and neuroscience,
G Lantz, and
C M Michel, and
M Seeck, and
O Blanke, and
T Landis, and
I Rosén
December 1998,
Neuroreport,
