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Two transplant procedures have been investigated in which one third of the pancreas was autotransplanted into the splenic pulp of dogs. The two procedures consist of simple mechanical dissociation of the pancreas or mechanical dissociation followed by collagenase digestion. The ability of the endocrine segment of the transplant to survive and function was assessed by stimulation with arginine and measurement of insulin and glucagon response. The results demonstrate that both transplant procedures result in functioning beta and alpha cells that rapidly secrete both insulin and glucagon in response to arginine stimulation. However, greater insulin responses were obtained when mechanically dissociated but nonenzyme digested pancreatic tissue was used for transplantation. The spleen appears to be an excellent transplant site for the reception of endocrine pancreatic tissue and allowed both beta and alpha cells to survive following transplantation.
B N Gray, and
G Caruso, and
F Alford, and
D Chisholm
April 2013,
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons,
B N Gray, and
G Caruso, and
F Alford, and
D Chisholm
March 2013,
International journal of molecular sciences,
B N Gray, and
G Caruso, and
F Alford, and
D Chisholm
May 1985,
Naunyn-Schmiedeberg's archives of pharmacology,
B N Gray, and
G Caruso, and
F Alford, and
D Chisholm
June 1984,
Transplantation proceedings,
B N Gray, and
G Caruso, and
F Alford, and
D Chisholm
September 1970,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
B N Gray, and
G Caruso, and
F Alford, and
D Chisholm
December 2004,
Magnetic resonance in medicine,
B N Gray, and
G Caruso, and
F Alford, and
D Chisholm
January 1999,
Journal of molecular medicine (Berlin, Germany),
B N Gray, and
G Caruso, and
F Alford, and
D Chisholm
October 2010,
Biochemical and biophysical research communications,
B N Gray, and
G Caruso, and
F Alford, and
D Chisholm
January 1977,
European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes,
B N Gray, and
G Caruso, and
F Alford, and
D Chisholm
November 1989,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
