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A non-nucleoside linker based upon the ligand 2,2'-bipyridine and ethylene glycol is prepared and placed into the backbone of a number of oligonucleo-tides. The bipyridine ligand is reacted with cis -dichloro bis(2,2'-bipyridyl) Ru(II) to generate the relatively substitutionally inert complex based upon the well-characterized tris -2,2'-bipyridyl Ru(II). The ruthenium-containing DNA complexes exhibited UV and fluorescence characteristics that are consistent with those previously observed for simple tris -2,2'-bipyridyl Ru(II) complexes. Oligonucleotides containing the ruthenium complex will form both DNA duplexes and triplexes with stabilities that are slightly better than those formed from simple tethered oligonucleotide probes in which the two hybridizing sequences are tethered by simple tri(ethylene glycol) or hexa(ethylene glycol) linkers.
K Wiederholt, and
L W McLaughlin
May 2008,
Organic letters,
K Wiederholt, and
L W McLaughlin
November 2006,
Inorganic chemistry,
K Wiederholt, and
L W McLaughlin
April 2004,
Dalton transactions (Cambridge, England : 2003),
K Wiederholt, and
L W McLaughlin
August 2016,
Chemical communications (Cambridge, England),
K Wiederholt, and
L W McLaughlin
May 2013,
Inorganic chemistry,
K Wiederholt, and
L W McLaughlin
June 2007,
The journal of physical chemistry. B,
K Wiederholt, and
L W McLaughlin
June 2008,
Dalton transactions (Cambridge, England : 2003),
K Wiederholt, and
L W McLaughlin
September 1968,
Proceedings of the National Academy of Sciences of the United States of America,
K Wiederholt, and
L W McLaughlin
February 1999,
Inorganic chemistry,
K Wiederholt, and
L W McLaughlin
November 2002,
Bioorganic & medicinal chemistry letters,
