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Gastric antiulcerogenic effects of Stryphnodendron adstringens in rats. 1999
E A Audi, and
D P Toledo, and
P G Peres, and
E Kimura, and
W K Pereira, and
J C de Mello, and
C Nakamura, and
W Alves-do-Prado, and
R K Cuman, and
C A Bersani-Amado
Departmento de Farmácia e Farmacologia da Universidade Estadual de Maringá, Pr., Brazil.
The antiulcer activity of the total extract and the fractions of Stryphnodendron adstringens was studied in rats and compared with that of cimetidine. Ulcers were induced in rats by means of three experimental models: acute stress, acidified-ethanol and indomethacin. The total extract and the fractions were found to have significant antiulcer activity in the case of the acute stress and acidified-ethanol models. These findings support the use of S. adstringens extracts in the treatment of gastric lesions.
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