-transparent.png){kind=logo}
The title compounds were synthesized by replacing the thiophene moiety of A-86929(2a) with variously substituted pyridines. Dopamine D-1 and D-2 binding and adenylate cyclase assays indicate that 4,6-diaza compounds 15 are potent and selective full D1 agonists when R1 is H or a small substituent and R2 = H, with D1 binding affinity and adenylate cyclase functional potency equivalent to that of A-86929(2a).
Related Publications
Y G Gu, and
E K Bayburt, and
M R Michaelides, and
C W Lin, and
K Shiosaki
January 1997,
The Journal of organic chemistry,
Y G Gu, and
E K Bayburt, and
M R Michaelides, and
C W Lin, and
K Shiosaki
June 1990,
Journal of medicinal chemistry,
Y G Gu, and
E K Bayburt, and
M R Michaelides, and
C W Lin, and
K Shiosaki
January 1995,
Journal of medicinal chemistry,
Y G Gu, and
E K Bayburt, and
M R Michaelides, and
C W Lin, and
K Shiosaki
May 1987,
Carcinogenesis,
Y G Gu, and
E K Bayburt, and
M R Michaelides, and
C W Lin, and
K Shiosaki
April 2000,
Biochemistry,
Y G Gu, and
E K Bayburt, and
M R Michaelides, and
C W Lin, and
K Shiosaki
January 1965,
American Industrial Hygiene Association journal,
Y G Gu, and
E K Bayburt, and
M R Michaelides, and
C W Lin, and
K Shiosaki
March 2006,
Bioorganic & medicinal chemistry letters,
Y G Gu, and
E K Bayburt, and
M R Michaelides, and
C W Lin, and
K Shiosaki
December 2000,
Arzneimittel-Forschung,
Y G Gu, and
E K Bayburt, and
M R Michaelides, and
C W Lin, and
K Shiosaki
July 1977,
Journal of medicinal chemistry,
Y G Gu, and
E K Bayburt, and
M R Michaelides, and
C W Lin, and
K Shiosaki
May 2003,
Bioorganic & medicinal chemistry letters,
