-transparent.png){kind=logo}
Piperidine-renin inhibitors compounds with improved physicochemical properties. 1999
R Güller, and
A Binggeli, and
V Breu, and
D Bur, and
W Fischli, and
G Hirth, and
C Jenny, and
M Kansy, and
F Montavon, and
M Müller, and
C Oefner, and
H Stadler, and
E Vieira, and
M Wilhelm, and
W Wostl, and
H P Märki
Pharma Research Department, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
Piperidine renin inhibitors with heterocyclic core modifications or hydrophilic attachments show improved physical properties (lower lipophilicity, improved solubility). Tetrahydroquinoline derivative rac-30 with a molecular weight of 517 and a log D(pH 7.4) of 1.9 displays potent and long lasting blood pressure lowering effects after oral administration to sodium depleted conscious marmosets.
Related Publications
R Güller, and
A Binggeli, and
V Breu, and
D Bur, and
W Fischli, and
G Hirth, and
C Jenny, and
M Kansy, and
F Montavon, and
M Müller, and
C Oefner, and
H Stadler, and
E Vieira, and
M Wilhelm, and
W Wostl, and
H P Märki
May 1992,
Journal of medicinal chemistry,
R Güller, and
A Binggeli, and
V Breu, and
D Bur, and
W Fischli, and
G Hirth, and
C Jenny, and
M Kansy, and
F Montavon, and
M Müller, and
C Oefner, and
H Stadler, and
E Vieira, and
M Wilhelm, and
W Wostl, and
H P Märki
July 2009,
Bioorganic & medicinal chemistry,
R Güller, and
A Binggeli, and
V Breu, and
D Bur, and
W Fischli, and
G Hirth, and
C Jenny, and
M Kansy, and
F Montavon, and
M Müller, and
C Oefner, and
H Stadler, and
E Vieira, and
M Wilhelm, and
W Wostl, and
H P Märki
November 2010,
Bioorganic & medicinal chemistry letters,
R Güller, and
A Binggeli, and
V Breu, and
D Bur, and
W Fischli, and
G Hirth, and
C Jenny, and
M Kansy, and
F Montavon, and
M Müller, and
C Oefner, and
H Stadler, and
E Vieira, and
M Wilhelm, and
W Wostl, and
H P Märki
April 2012,
ChemMedChem,
R Güller, and
A Binggeli, and
V Breu, and
D Bur, and
W Fischli, and
G Hirth, and
C Jenny, and
M Kansy, and
F Montavon, and
M Müller, and
C Oefner, and
H Stadler, and
E Vieira, and
M Wilhelm, and
W Wostl, and
H P Märki
December 2016,
Bioorganic & medicinal chemistry letters,
R Güller, and
A Binggeli, and
V Breu, and
D Bur, and
W Fischli, and
G Hirth, and
C Jenny, and
M Kansy, and
F Montavon, and
M Müller, and
C Oefner, and
H Stadler, and
E Vieira, and
M Wilhelm, and
W Wostl, and
H P Märki
February 2019,
Bioorganic & medicinal chemistry letters,
R Güller, and
A Binggeli, and
V Breu, and
D Bur, and
W Fischli, and
G Hirth, and
C Jenny, and
M Kansy, and
F Montavon, and
M Müller, and
C Oefner, and
H Stadler, and
E Vieira, and
M Wilhelm, and
W Wostl, and
H P Märki
January 2005,
Bioorganic & medicinal chemistry,
R Güller, and
A Binggeli, and
V Breu, and
D Bur, and
W Fischli, and
G Hirth, and
C Jenny, and
M Kansy, and
F Montavon, and
M Müller, and
C Oefner, and
H Stadler, and
E Vieira, and
M Wilhelm, and
W Wostl, and
H P Märki
February 1967,
Archives internationales de pharmacodynamie et de therapie,
R Güller, and
A Binggeli, and
V Breu, and
D Bur, and
W Fischli, and
G Hirth, and
C Jenny, and
M Kansy, and
F Montavon, and
M Müller, and
C Oefner, and
H Stadler, and
E Vieira, and
M Wilhelm, and
W Wostl, and
H P Märki
May 2018,
Prostaglandins & other lipid mediators,
R Güller, and
A Binggeli, and
V Breu, and
D Bur, and
W Fischli, and
G Hirth, and
C Jenny, and
M Kansy, and
F Montavon, and
M Müller, and
C Oefner, and
H Stadler, and
E Vieira, and
M Wilhelm, and
W Wostl, and
H P Märki
October 2007,
Dental materials : official publication of the Academy of Dental Materials,
