Biomaterial Database

Motor unit action potential components and physiologic duration. 1999

D Dumitru, and J C King, and W E Rogers

University of Texas Health Science Center at San Antonio, Department of Rehabilitation Medicine, 78284-7798, USA.

Motor unit action potentials (MUAPs) recorded from the same motor unit at two distances along the biceps brachii muscle with monopolar needle electrodes at high amplifier gains (20 microV/division) and averaged 2000-3000 times reveal total potential durations of 39.6 +/- 4.6 ms. In addition, the terminal segment for each of these two MUAPs contained a late far-field potential with a mean duration of 23.8 +/- 4.1 ms. Computer simulations of MUAPs suggest that this long-duration positive far-field mirrors the true morphology of the intracellular action potential (IAP), which is monophasic positive, possessing a terminal repolarization phase approaching 30 ms. This investigation suggests that the MUAP's physiologic duration is directly proportional to the muscle fiber length and the IAP's duration, which becomes manifest as a positive far-field potential when the IAP encounters the musculotendinous junction and slowly dissipates. The leading/trailing dipole model is used to explain qualitatively this study's quantitative clinical and computer simulation findings.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009046	Motor Neurons	Neurons which activate MUSCLE CELLS.	Neurons, Motor,Alpha Motorneurons,Motoneurons,Motor Neurons, Alpha,Neurons, Alpha Motor,Alpha Motor Neuron,Alpha Motor Neurons,Alpha Motorneuron,Motoneuron,Motor Neuron,Motor Neuron, Alpha,Motorneuron, Alpha,Motorneurons, Alpha,Neuron, Alpha Motor,Neuron, Motor
D003198	Computer Simulation	Computer-based representation of physical systems and phenomena such as chemical processes.	Computational Modeling,Computational Modelling,Computer Models,In silico Modeling,In silico Models,In silico Simulation,Models, Computer,Computerized Models,Computer Model,Computer Simulations,Computerized Model,In silico Model,Model, Computer,Model, Computerized,Model, In silico,Modeling, Computational,Modeling, In silico,Modelling, Computational,Simulation, Computer,Simulation, In silico,Simulations, Computer
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000200	Action Potentials	Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.	Spike Potentials,Nerve Impulses,Action Potential,Impulse, Nerve,Impulses, Nerve,Nerve Impulse,Potential, Action,Potential, Spike,Potentials, Action,Potentials, Spike,Spike Potential
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor
D018485	Muscle Fibers, Skeletal	Large, multinucleate single cells, either cylindrical or prismatic in shape, that form the basic unit of SKELETAL MUSCLE. They consist of MYOFIBRILS enclosed within and attached to the SARCOLEMMA. They are derived from the fusion of skeletal myoblasts (MYOBLASTS, SKELETAL) into a syncytium, followed by differentiation.	Myocytes, Skeletal,Myotubes,Skeletal Myocytes,Skeletal Muscle Fibers,Fiber, Skeletal Muscle,Fibers, Skeletal Muscle,Muscle Fiber, Skeletal,Myocyte, Skeletal,Myotube,Skeletal Muscle Fiber,Skeletal Myocyte