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A radioimmunoassay for the antidiabetic drug 3-(4-[beta-(5-methyl-isoxazol-3-carboxyamido)-ethyl]-benzenesulfonyl)-ureido-piperidine-4-carboxic acid (glisoxepide, I, Pro-Diaban) is described. Antisera were obtained by immunizing rabbits with a piperidine carboxylic acid analogue of glisoxepide coupled to bovine serum albumine. The carboxylic acid analogue coupled to [3H]-1-tyrosine methyl ester was used as the tracer. Antisera with high sensitivity were obtained. With some glisoxepide analogues the specificity of the antisera was investigated. For good binding the isoxazole and the benzene ring as well as the appropriate distance between both rings are essential. The assay can be carried out without extraction of the compound from the serum. Dextran coated charcoal is used for separation of free and bound glisoxepide.
B Nieuweboer, and
D Gabriel, and
K Lübke
October 1977,
Casopis lekaru ceskych,
B Nieuweboer, and
D Gabriel, and
K Lübke
November 1974,
Zeitschrift fur klinische Chemie und klinische Biochemie,
B Nieuweboer, and
D Gabriel, and
K Lübke
November 1976,
Deutsche medizinische Wochenschrift (1946),
B Nieuweboer, and
D Gabriel, and
K Lübke
January 1975,
Radiobiologia, radiotherapia,
B Nieuweboer, and
D Gabriel, and
K Lübke
April 1980,
Zeitschrift fur Geburtshilfe und Perinatologie,
B Nieuweboer, and
D Gabriel, and
K Lübke
October 1978,
Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie,
B Nieuweboer, and
D Gabriel, and
K Lübke
May 1981,
Pathologie-biologie,
B Nieuweboer, and
D Gabriel, and
K Lübke
July 1978,
Jikken dobutsu. Experimental animals,
B Nieuweboer, and
D Gabriel, and
K Lübke
March 1979,
Ceskoslovenska epidemiologie, mikrobiologie, imunologie,
B Nieuweboer, and
D Gabriel, and
K Lübke
January 1975,
Radiologia diagnostica,
