Evidence-based medicine indicates continuous and systematic use of the results of clinical research in everyday clinical practice. It is an important aid to avoid biases of medical decisions caused by following subjective opinion, tradition without criticism or extrapolation from observations at molecular or cellular level. The conscientious use of current best evidence in making decisions about the care of individual patient is an important guarantee of quality. The authors present the details of evidence-based medicine, the main steps of exploring and synthesising evidences.