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OBJECTIVE Catheter-related sepsis is an important complication associated with the use of central venous catheters. Recent studies have suggested that antimicrobial-bonded catheters may reduce catheter colonization and catheter-related sepsis. The aim of this study was to determine the relationship between the antimicrobial activity and the colonization rate of two commercially available antimicrobial-bonded central venous catheters. METHODS Prospective, randomized, controlled, nonblinded study. METHODS Medical intensive care unit of a university-affiliated teaching hospital. METHODS One hundred twenty consecutive medical intensive care unit patients requiring new central venous catheters (fresh stick). METHODS Patients were randomized to receive a) a Standard Arrow; b) an ARROWgard; or c) a Cook Bio-Guard Spectrum central venous catheter. Central venous catheters were removed when they were no longer required or when catheter-related sepsis was suspected. Under aseptic conditions, the distal 12 cm of the removed catheters were cut into six 2-cm segments. Semiquantitative culture was performed (by roll technique) on the distal segment. Colonization was defined as >15 colony-forming units. Using a modified Kirby-Bauer technique, the zone of inhibition of the remaining five segments was determined against the following organisms: methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis, Enterococcus faecalis, Acinetobacter baumannii, and Candida albicans Catheters that were removed within 24 hrs of insertion were excluded from the analysis. RESULTS Seven patients were not assessable. The baseline clinical and demographic characteristics were similar among the three groups of patients. Eleven Standard Arrow (28%), seven ARROWgard (19%), and four Bio-Guard (11%) catheters were colonized (p = .05 for Bio-Guard vs. control). Staphylococci were the most common colonizing organisms. Two patients with Standard Arrow catheters (5%) and one patient with an ARROWgard catheter (3%) developed catheter-related sepsis. Antibiotic-coated catheters significantly inhibited the growth of all test organisms except C. albicans (p < or = .05). Zones of inhibition were significantly larger for the Bio-Guard compared with the ARROWgard catheter when tested against MRSA, S. epidermidis, and E. faecalis (p < or = .002). CONCLUSIONS The Bio-Guard central venous catheter had greater ex vivo antimicrobial activity against MRSA, S. epidermidis, and E. faecalis compared with the ARROWgard catheter, and this was associated with a significantly lower rate of catheter colonization.
P E Marik, and
G Abraham, and
P Careau, and
J Varon, and
R E Fromm
February 1996,
The Journal of antimicrobial chemotherapy,
P E Marik, and
G Abraham, and
P Careau, and
J Varon, and
R E Fromm
April 1984,
Southern medical journal,
P E Marik, and
G Abraham, and
P Careau, and
J Varon, and
R E Fromm
January 2017,
Antimicrobial resistance and infection control,
P E Marik, and
G Abraham, and
P Careau, and
J Varon, and
R E Fromm
June 1999,
The New England journal of medicine,
P E Marik, and
G Abraham, and
P Careau, and
J Varon, and
R E Fromm
June 1999,
The New England journal of medicine,
P E Marik, and
G Abraham, and
P Careau, and
J Varon, and
R E Fromm
June 1999,
The New England journal of medicine,
P E Marik, and
G Abraham, and
P Careau, and
J Varon, and
R E Fromm
June 1999,
The New England journal of medicine,
P E Marik, and
G Abraham, and
P Careau, and
J Varon, and
R E Fromm
January 2002,
The Pediatric infectious disease journal,
P E Marik, and
G Abraham, and
P Careau, and
J Varon, and
R E Fromm
September 1999,
Anaesthesia,
P E Marik, and
G Abraham, and
P Careau, and
J Varon, and
R E Fromm
September 2000,
Critical care medicine,
