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OBJECTIVE Microvascular alterations, impairment of coagulation, ischemia and diffuse endothelial damage are related to the progression of diabetic retinopathy. Defibrotide has been demonstrated to produce profibrinolytic, cytoprotective and vasofacilatory activities. The aim of the present study was to evaluate the therapeutic effect of Defibrotide in the treatment of nonproliferative diabetic retinopathy. METHODS Two randomized age- and sex-matched groups (cases and controls) of 35 NIDDM patients presenting non-proliferative diabetic retinopathy were included in this study: cases were treated with Defibrotide (800-1600 mg daily) for two years. RESULTS All tested parameters (ETDRS visual acuity; computerized perimetry; retinography; fluorescein angiography), improved significantly (p<0.001) in Defibrotide-treated patients compared to controls. In our opinion, Defibrotide's manifold effects on vascular endothelia may account for this improvement by stimulation of tPA, PGI2, PGE2, thrombomodulin and modulation of endothelin-1 release. CONCLUSIONS Our preliminary data seem to suggest that Defibrotide could be proposed for medical treatment of nonproliferative diabetic retinopathy.
E M Vingolo, and
G De Mattia, and
C Giusti, and
R Forte, and
O Laurenti, and
M R Pannarale
January 2013,
Clinical ophthalmology (Auckland, N.Z.),
E M Vingolo, and
G De Mattia, and
C Giusti, and
R Forte, and
O Laurenti, and
M R Pannarale
July 1991,
American family physician,
E M Vingolo, and
G De Mattia, and
C Giusti, and
R Forte, and
O Laurenti, and
M R Pannarale
February 1993,
The New Zealand medical journal,
E M Vingolo, and
G De Mattia, and
C Giusti, and
R Forte, and
O Laurenti, and
M R Pannarale
March 1993,
The New Zealand medical journal,
E M Vingolo, and
G De Mattia, and
C Giusti, and
R Forte, and
O Laurenti, and
M R Pannarale
June 1983,
Clinical pharmacology and therapeutics,
E M Vingolo, and
G De Mattia, and
C Giusti, and
R Forte, and
O Laurenti, and
M R Pannarale
March 1991,
Israel journal of medical sciences,
E M Vingolo, and
G De Mattia, and
C Giusti, and
R Forte, and
O Laurenti, and
M R Pannarale
July 2004,
International ophthalmology,
E M Vingolo, and
G De Mattia, and
C Giusti, and
R Forte, and
O Laurenti, and
M R Pannarale
January 1995,
Retina (Philadelphia, Pa.),
E M Vingolo, and
G De Mattia, and
C Giusti, and
R Forte, and
O Laurenti, and
M R Pannarale
January 2020,
Journal of diabetes research,
E M Vingolo, and
G De Mattia, and
C Giusti, and
R Forte, and
O Laurenti, and
M R Pannarale
September 1996,
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan,
