-transparent.png){kind=logo}
We studied adenosine deaminase (ADA) activity in bronchoalveolar lavage fluid (BALF) specimens from 24 patients with sarcoidosis. Mean BALF-ADA activity was significantly (p < 0.0001) elevated in patients with sarcoidosis (1.02 +/- 1.01 IU/L, mean +/- SD) compared to the subjects in a healthy control group (0.08 +/- 0.29 IU/L). In the sarcoidosis patients with high BALF-ADA activity (> or = 1.0 IU/L), AaDO2 was significantly (p < 0.0001) elevated compared to its level in patients with normal BALF-ADA activity (< 1.0 IU/L). BALF-ADA activity was significantly (p < 0.01) higher in patients who exhibited lung-field accumulations on 67Ga scintigrams compared to those with no accumulations, and significantly (p < 0.001) higher in patients undergoing corticosteroid treatment compared to in those patients who did not receive such treatment. These findings were similar to the results of studies using data on BALF-ADA/albumin ratios. Furthermore, they suggest that the localized production of ADA may increase in sarcoidosis patients displaying 67Ga scintigram lung-field accumulations with increased AaDO2, and that BALF-ADA activity may be a useful indicator of disease activity and the need for treatment.
M Kubota, and
M Katagiri, and
T Imasaki, and
N Yanase, and
K Soma, and
T Tomita
November 1988,
Chest,
M Kubota, and
M Katagiri, and
T Imasaki, and
N Yanase, and
K Soma, and
T Tomita
March 1993,
Sarcoidosis,
M Kubota, and
M Katagiri, and
T Imasaki, and
N Yanase, and
K Soma, and
T Tomita
February 1998,
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease,
M Kubota, and
M Katagiri, and
T Imasaki, and
N Yanase, and
K Soma, and
T Tomita
December 2021,
International journal of clinical practice,
M Kubota, and
M Katagiri, and
T Imasaki, and
N Yanase, and
K Soma, and
T Tomita
January 1986,
Annals of the New York Academy of Sciences,
M Kubota, and
M Katagiri, and
T Imasaki, and
N Yanase, and
K Soma, and
T Tomita
September 2004,
The Southeast Asian journal of tropical medicine and public health,
M Kubota, and
M Katagiri, and
T Imasaki, and
N Yanase, and
K Soma, and
T Tomita
July 2002,
Respiratory medicine,
M Kubota, and
M Katagiri, and
T Imasaki, and
N Yanase, and
K Soma, and
T Tomita
December 1987,
Thorax,
M Kubota, and
M Katagiri, and
T Imasaki, and
N Yanase, and
K Soma, and
T Tomita
August 1986,
The American review of respiratory disease,
M Kubota, and
M Katagiri, and
T Imasaki, and
N Yanase, and
K Soma, and
T Tomita
January 1990,
Japanese journal of medicine,
