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Germ-free BALB/c mice, genetically engineered to be deficient for interleukin-8 (IL-8) receptor homolog (IL-8Rh-/-), were more susceptible to gastric candidiasis after oral challenge and to acute systemic candidiasis after intravenous challenge than IL-8Rh+/+ controls. In comparison to IL-8Rh+/+ mice, the IL-8Rh-/- mice had slower influx of polymorphonuclear neutrophils (PMN) into Candida albicans-infected tissues and a lower percentage of PMN in peritoneal exudate cells (PEC) elicited with heat-killed C. albicans. PEC from IL-8Rh-/- mice exhibited less luminol-dependent chemiluminescence in response to C. albicans and did not kill C. albicans hyphae as well as PEC from IL-8Rh+/+ mice. C. albicans-colonized IL-8Rh-/- mice showed no histological evidence of systemic candidiasis. These results suggest a role for the IL-8Rh in murine resistance to gastric and acute systemic candidiasis, but not in resistance to systemic candidiasis of endogenous origin.
E Balish, and
R D Wagner, and
A Vazquez-Torres, and
J Jones-Carson, and
C Pierson, and
T Warner
April 1990,
Infection and immunity,
E Balish, and
R D Wagner, and
A Vazquez-Torres, and
J Jones-Carson, and
C Pierson, and
T Warner
April 2011,
Mikrobiyoloji bulteni,
E Balish, and
R D Wagner, and
A Vazquez-Torres, and
J Jones-Carson, and
C Pierson, and
T Warner
November 1989,
Infection and immunity,
E Balish, and
R D Wagner, and
A Vazquez-Torres, and
J Jones-Carson, and
C Pierson, and
T Warner
December 2015,
Auris, nasus, larynx,
E Balish, and
R D Wagner, and
A Vazquez-Torres, and
J Jones-Carson, and
C Pierson, and
T Warner
August 2017,
Auris, nasus, larynx,
E Balish, and
R D Wagner, and
A Vazquez-Torres, and
J Jones-Carson, and
C Pierson, and
T Warner
March 2016,
Current medical mycology,
E Balish, and
R D Wagner, and
A Vazquez-Torres, and
J Jones-Carson, and
C Pierson, and
T Warner
July 2016,
Scientific reports,
E Balish, and
R D Wagner, and
A Vazquez-Torres, and
J Jones-Carson, and
C Pierson, and
T Warner
January 2000,
European journal of immunology,
E Balish, and
R D Wagner, and
A Vazquez-Torres, and
J Jones-Carson, and
C Pierson, and
T Warner
January 1974,
Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie,
E Balish, and
R D Wagner, and
A Vazquez-Torres, and
J Jones-Carson, and
C Pierson, and
T Warner
December 2012,
Journal de mycologie medicale,
