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Senescence of Podospora anserina is triggered by a cytoplasmic and infectious factor (the determinant of senescence) and is always correlated with mitochondrial DNA modifications, especially with the accumulation of small circular subgenomic DNA molecules, the senDNAs. Several observations have suggested that the senDNAs could be the cytoplasmic and infectious determinant. However, we show here (1) that senDNA molecules can be transferred to a young culture without the cotransmission of the determinant of senescence and (2) that the determinant of senescence does not segregate as a mitochondrial DNA mutation. Overall, our data strongly argue that amplification of senDNA molecules in the mitochondria is not an intrinsic property of these small DNA molecules. They question the nature of the actual determinant of senescence.
C Jamet-Vierny, and
M Rossignol, and
V Haedens, and
P Silar
September 1981,
Current genetics,
C Jamet-Vierny, and
M Rossignol, and
V Haedens, and
P Silar
September 1981,
Current genetics,
C Jamet-Vierny, and
M Rossignol, and
V Haedens, and
P Silar
February 1976,
Molecular & general genetics : MGG,
C Jamet-Vierny, and
M Rossignol, and
V Haedens, and
P Silar
December 2022,
Trends in microbiology,
C Jamet-Vierny, and
M Rossignol, and
V Haedens, and
P Silar
April 2000,
Proceedings of the National Academy of Sciences of the United States of America,
C Jamet-Vierny, and
M Rossignol, and
V Haedens, and
P Silar
November 1983,
Current genetics,
C Jamet-Vierny, and
M Rossignol, and
V Haedens, and
P Silar
August 1980,
Cell,
C Jamet-Vierny, and
M Rossignol, and
V Haedens, and
P Silar
June 1982,
Cell,
C Jamet-Vierny, and
M Rossignol, and
V Haedens, and
P Silar
May 1979,
Molecular & general genetics : MGG,
C Jamet-Vierny, and
M Rossignol, and
V Haedens, and
P Silar
January 1984,
Monographs in developmental biology,
