Nasal hyperreactivity. 1999

R G Gerth van Wijk, and C de Graaf-in 't Veld, and I M Garrelds
Dept. of Allergology, University Hospital Rotterdam, The Netherlands.

Nasal hyperreactivity is an important feature of allergic and non-allergic rhinitis. This paper reviews the possible mechanisms behind hyperreactivity. Distinct mechanisms may play a role in allergic rhinitis--an inflammatory disease--and non-allergic rhinitis, mainly a non-inflammatory disease. In allergic rhinitis, particularly in perennial allergic rhinitis, there is a close connection between allergic response and non-specific hyperreactivity. In non-allergic rhinitis, a pathological entity comprising a heterogeneous series of diseases, understanding and measuring nasal hyperreactivity is much more difficult. A variety of methods to assess nasal hyperreactivity are available. Given the heterogeneity of mechanisms, the various patients groups and the lack of standardization in tests, it is not surprising that measurement of nasal hyperreactivity is not included in the diagnostic arsenal of the clinician.

UI MeSH Term Description Entries
D006967 Hypersensitivity Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen. Allergy,Allergic Reaction,Allergic Reactions,Allergies,Hypersensitivities,Reaction, Allergic,Reactions, Allergic
D008297 Male Males
D009297 Nasal Mucosa The mucous lining of the NASAL CAVITY, including lining of the nostril (vestibule) and the OLFACTORY MUCOSA. Nasal mucosa consists of ciliated cells, GOBLET CELLS, brush cells, small granule cells, basal cells (STEM CELLS) and glands containing both mucous and serous cells. Nasal Epithelium,Schneiderian Membrane,Epithelium, Nasal,Membrane, Schneiderian,Mucosa, Nasal
D009299 Nasal Provocation Tests Application of allergens to the nasal mucosa. Interpretation includes observation of nasal symptoms, rhinoscopy, and rhinomanometry. Nasal provocation tests are used in the diagnosis of nasal hypersensitivity, including RHINITIS, ALLERGIC, SEASONAL. Provocation Tests, Nasal,Nasal Provocation Test,Provocation Test, Nasal,Test, Nasal Provocation,Tests, Nasal Provocation
D003937 Diagnosis, Differential Determination of which one of two or more diseases or conditions a patient is suffering from by systematically comparing and contrasting results of diagnostic measures. Diagnoses, Differential,Differential Diagnoses,Differential Diagnosis
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000485 Allergens Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE). Allergen
D001249 Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL). Asthma, Bronchial,Bronchial Asthma,Asthmas
D012221 Rhinitis, Allergic, Perennial Inflammation of the mucous membrane of the nose similar to that found in hay fever except that symptoms persist throughout the year. The causes are usually air-borne allergens, particularly dusts, feathers, molds, animal fur, etc. Rhinitis, Allergic, Nonseasonal

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