-transparent.png){kind=logo}
The total solid-phase synthesis of polymyxin B1 (PMB1) has been achieved in 20% yield using the orthogonal protecting group N-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl-(Dde). This report demonstrates that a complex peptide macrocycle can be synthesized in high yields using solid-phase synthesis. According to MS and HPLC, the synthetic peptide was identical to the naturally occurring antibiotic.
Related Publications
S K Sharma, and
A D Wu, and
N Chandramouli, and
C Fotsch, and
G Kardash, and
K W Bair
June 2003,
The journal of peptide research : official journal of the American Peptide Society,
S K Sharma, and
A D Wu, and
N Chandramouli, and
C Fotsch, and
G Kardash, and
K W Bair
May 1974,
Journal of the American Chemical Society,
S K Sharma, and
A D Wu, and
N Chandramouli, and
C Fotsch, and
G Kardash, and
K W Bair
February 2016,
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,
S K Sharma, and
A D Wu, and
N Chandramouli, and
C Fotsch, and
G Kardash, and
K W Bair
November 2003,
The Journal of organic chemistry,
S K Sharma, and
A D Wu, and
N Chandramouli, and
C Fotsch, and
G Kardash, and
K W Bair
June 1996,
The Journal of organic chemistry,
S K Sharma, and
A D Wu, and
N Chandramouli, and
C Fotsch, and
G Kardash, and
K W Bair
January 2013,
Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia,
S K Sharma, and
A D Wu, and
N Chandramouli, and
C Fotsch, and
G Kardash, and
K W Bair
March 2022,
Organic letters,
S K Sharma, and
A D Wu, and
N Chandramouli, and
C Fotsch, and
G Kardash, and
K W Bair
December 1980,
Die Pharmazie,
S K Sharma, and
A D Wu, and
N Chandramouli, and
C Fotsch, and
G Kardash, and
K W Bair
December 2018,
The Journal of organic chemistry,
S K Sharma, and
A D Wu, and
N Chandramouli, and
C Fotsch, and
G Kardash, and
K W Bair
November 2001,
The Journal of organic chemistry,
