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Dendritic cells (DCs) are special subsets of antigen-presenting cells characterized by their highly potent capacity to activate immunologically naive T cells. Here we report that DCs that are transfected with CD95 ligand (CD95L) cDNA, called 'killer' DCs, deliver death signals, instead of activation signals, to T cells after antigen-specific interaction. Injection of antigen-pulsed killer DCs into mice before sensitization induced antigen-specific immunosuppression. When administered after sensitization, killer DCs suppressed immune responses almost completely after subsequent challenge. Thus, killer DCs represent an entirely new immunomodulatory protocol, which may become directly applicable in preventing and even treating T cell-mediated inflammatory diseases.
H Matsue, and
K Matsue, and
M Walters, and
K Okumura, and
H Yagita, and
A Takashima
May 2011,
Immunology,
H Matsue, and
K Matsue, and
M Walters, and
K Okumura, and
H Yagita, and
A Takashima
June 2008,
Clinical immunology (Orlando, Fla.),
H Matsue, and
K Matsue, and
M Walters, and
K Okumura, and
H Yagita, and
A Takashima
January 1998,
Advances in experimental medicine and biology,
H Matsue, and
K Matsue, and
M Walters, and
K Okumura, and
H Yagita, and
A Takashima
January 2001,
Transplantation proceedings,
H Matsue, and
K Matsue, and
M Walters, and
K Okumura, and
H Yagita, and
A Takashima
October 2008,
Cancer immunology, immunotherapy : CII,
H Matsue, and
K Matsue, and
M Walters, and
K Okumura, and
H Yagita, and
A Takashima
December 2001,
Biotechnology and applied biochemistry,
H Matsue, and
K Matsue, and
M Walters, and
K Okumura, and
H Yagita, and
A Takashima
September 2005,
Journal of immunology (Baltimore, Md. : 1950),
H Matsue, and
K Matsue, and
M Walters, and
K Okumura, and
H Yagita, and
A Takashima
April 1998,
Nature biotechnology,
H Matsue, and
K Matsue, and
M Walters, and
K Okumura, and
H Yagita, and
A Takashima
January 2001,
Journal of cancer research and clinical oncology,
H Matsue, and
K Matsue, and
M Walters, and
K Okumura, and
H Yagita, and
A Takashima
November 1998,
Nature biotechnology,
