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Local low-dose IL-2 therapy. 1999
W Den Otter, and
L Balemans, and
J J Battermann, and
M R Bernsen, and
J A Cadee, and
Z Dobrowolski, and
L A Everse, and
L Fiszer-Maliszewska, and
R Gavhumende, and
J W De Groot, and
K De Groot, and
W E Hennink, and
F W Hill, and
I Jurgenliemp-Schulz, and
W R Klein, and
J W Koten, and
R A Maas, and
P Steerenberg, and
R Stewart, and
M Zembala
Department of Cell Biology, Utrecht University, The Netherlands. w.denotter@pobox.accu.uu.nl
Interleukin-2 (IL-2) is a powerful drug for treating cancer. However, it is only powerful if it is properly applied. That is, IL-2 should be applied at the tumor site, because at the transition of normal and malignant tissue are the tumor infiltrating cells. These should be activated by IL-2. Local application implies that IL-2 can be used in relatively low doses. It is becoming clear that even a single injection of IL-2 can cure cancer. IL-2 can also enhance the therapeutic effects of irradiation and Cisplatin. Locally applied IL-2 therapy is virtually non-toxic.
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