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Reasons and limits of substrate activity of modified L-dNTP in DNA biosynthesis. 1999
A A Krayevsky, and
N B Dyatkina, and
D G Semizarov, and
L S Victorova, and
E A Shirokova, and
F Theil, and
M J Von Janta Lipinski, and
G Gosselin, and
J L Imbach
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Theoretical and experimental analysis of interaction of modified D- and L- dNTP as substrates for template-dependent and template-independent DNA polymerases was performed. It is shown that if the modified nucleoside 5'-triphosphates do not contain a substituent in position 3' DNA chains can be extended by both strereoisomeric series with the same kinetic parameters. But the presence of even a 3'-hydroxy group in L-dNTP prevents their incorporation into the DNA chain.
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