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Prodrugs of Ara-CMP and Ara-AMP with a S-acyl-2-thioethyl (SATE) biolabile phosphate protecting group: synthesis and biological evaluation. 1999
R Bazzanini, and
S Manfredini, and
E Durini, and
B Gröschel, and
J Cinatl, and
J Balzarini, and
E De Clercq, and
J L Imbach, and
C Périgaud, and
G Gosselin
Consiglio Nazionale delle Ricerche, I.Co.C.E.A., Bologna, Italy. r_bazzanini@area.bo.cnr.it
The bis(S-pivaloyl-2-thioethyl) phosphotriesters of Ara-C and Ara-A were synthesized as potential bioreversible mononucleotide prodrugs. Some N- and O-acylated derivatives were also prepared with the aim to modify the lipophilicity of the title pronucleotides. Compounds were tested for their antitumor/antiviral activity against a variety of tumor cells and viruses.
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Antiviral research,
