BIOMAT Database Logo BIOMAT Database Logo

Human DNA polymerases and retroviral reverse transcriptases: selectivity in respect to dNTPs modified at triphosphate residues. 1999

L S Victorova, and D G Semizarov, and E A Shirokova, and L A Alexandrova, and A A Arzumanov, and M V Jasko, and A A Krayevsky
Engelhardt Institute of Molecular Biology, RAS, Moscow, Russia.

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D009189 Avian Myeloblastosis Virus A species of ALPHARETROVIRUS causing anemia in fowl. Myeloblastosis Virus, Avian,Avian Myeloblastosis Viruses,Myeloblastosis Viruses, Avian,Virus, Avian Myeloblastosis,Viruses, Avian Myeloblastosis
D009711 Nucleotides The monomeric units from which DNA or RNA polymers are constructed. They consist of a purine or pyrimidine base, a pentose sugar, and a phosphate group. (From King & Stansfield, A Dictionary of Genetics, 4th ed) Nucleotide
D009943 Organophosphorus Compounds Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of synthetic compounds that are used as PESTICIDES and DRUGS. Organophosphorus Compound,Organopyrophosphorus Compound,Organopyrophosphorus Compounds,Compound, Organophosphorus,Compound, Organopyrophosphorus,Compounds, Organophosphorus,Compounds, Organopyrophosphorus
D002384 Catalysis The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction. Catalyses
D004259 DNA-Directed DNA Polymerase DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair. DNA Polymerase,DNA Polymerases,DNA-Dependent DNA Polymerases,DNA Polymerase N3,DNA Dependent DNA Polymerases,DNA Directed DNA Polymerase,DNA Polymerase, DNA-Directed,DNA Polymerases, DNA-Dependent,Polymerase N3, DNA,Polymerase, DNA,Polymerase, DNA-Directed DNA,Polymerases, DNA,Polymerases, DNA-Dependent DNA
D006678 HIV Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2. AIDS Virus,HTLV-III,Human Immunodeficiency Viruses,Human T-Cell Lymphotropic Virus Type III,Human T-Lymphotropic Virus Type III,LAV-HTLV-III,Lymphadenopathy-Associated Virus,Acquired Immune Deficiency Syndrome Virus,Acquired Immunodeficiency Syndrome Virus,Human Immunodeficiency Virus,Human T Cell Lymphotropic Virus Type III,Human T Lymphotropic Virus Type III,Human T-Cell Leukemia Virus Type III,Immunodeficiency Virus, Human,Immunodeficiency Viruses, Human,Virus, Human Immunodeficiency,Viruses, Human Immunodeficiency,AIDS Viruses,Human T Cell Leukemia Virus Type III,Lymphadenopathy Associated Virus,Lymphadenopathy-Associated Viruses,Virus, AIDS,Virus, Lymphadenopathy-Associated,Viruses, AIDS,Viruses, Lymphadenopathy-Associated
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012194 RNA-Directed DNA Polymerase An enzyme that synthesizes DNA on an RNA template. It is encoded by the pol gene of retroviruses and by certain retrovirus-like elements. EC 2.7.7.49. DNA Polymerase, RNA-Directed,RNA-Dependent DNA Polymerase,Reverse Transcriptase,RNA Transcriptase,Revertase,DNA Polymerase, RNA Directed,DNA Polymerase, RNA-Dependent,RNA Dependent DNA Polymerase,RNA Directed DNA Polymerase
D013379 Substrate Specificity A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts. Specificities, Substrate,Specificity, Substrate,Substrate Specificities

Related Publications

L S Victorova, and D G Semizarov, and E A Shirokova, and L A Alexandrova, and A A Arzumanov, and M V Jasko, and A A Krayevsky
dNTP modified at triphosphate residues: substrate properties towards DNA polymerases and stability in human serum.
January 1998, Nucleosides & nucleotides,
L S Victorova, and D G Semizarov, and E A Shirokova, and L A Alexandrova, and A A Arzumanov, and M V Jasko, and A A Krayevsky
The phage RNA polymerases are related to DNA polymerases and reverse transcriptases.
October 1993, Molecular microbiology,
L S Victorova, and D G Semizarov, and E A Shirokova, and L A Alexandrova, and A A Arzumanov, and M V Jasko, and A A Krayevsky
Selective action of 3'-azido-3'-deoxythymidine 5'-triphosphate on viral reverse transcriptases and human DNA polymerases.
July 1990, The Journal of biological chemistry,
L S Victorova, and D G Semizarov, and E A Shirokova, and L A Alexandrova, and A A Arzumanov, and M V Jasko, and A A Krayevsky
Polycitone A, a novel and potent general inhibitor of retroviral reverse transcriptases and cellular DNA polymerases.
November 1999, The Biochemical journal,
L S Victorova, and D G Semizarov, and E A Shirokova, and L A Alexandrova, and A A Arzumanov, and M V Jasko, and A A Krayevsky
Retroviral reverse transcriptases: error frequencies and mutagenesis.
January 1992, Current topics in microbiology and immunology,
L S Victorova, and D G Semizarov, and E A Shirokova, and L A Alexandrova, and A A Arzumanov, and M V Jasko, and A A Krayevsky
Incorporation of the guanosine triphosphate analogs 8-oxo-dGTP and 8-NH2-dGTP by reverse transcriptases and mammalian DNA polymerases.
February 1997, The Journal of biological chemistry,
L S Victorova, and D G Semizarov, and E A Shirokova, and L A Alexandrova, and A A Arzumanov, and M V Jasko, and A A Krayevsky
Fidelity of two retroviral reverse transcriptases during DNA-dependent DNA synthesis in vitro.
February 1989, Molecular and cellular biology,
L S Victorova, and D G Semizarov, and E A Shirokova, and L A Alexandrova, and A A Arzumanov, and M V Jasko, and A A Krayevsky
Inhibitory effects of 2'-deoxy-5-styryluridine 5'-triphosphate analogs on retroviral reverse transcriptase and eukaryotic DNA polymerases.
January 1992, Nucleic acids symposium series,
L S Victorova, and D G Semizarov, and E A Shirokova, and L A Alexandrova, and A A Arzumanov, and M V Jasko, and A A Krayevsky
Mutation rates and intrinsic fidelity of retroviral reverse transcriptases.
December 2009, Viruses,
L S Victorova, and D G Semizarov, and E A Shirokova, and L A Alexandrova, and A A Arzumanov, and M V Jasko, and A A Krayevsky
Molecular basis of fidelity of DNA synthesis and nucleotide specificity of retroviral reverse transcriptases.
January 2002, Progress in nucleic acid research and molecular biology,
Copied contents to your clipboard!