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We evaluated psychiatric symptoms and neurocognitive functioning among 25 institutionalized and 25 outpatient DSM-IV-diagnosed schizophrenia patients, as well as 25 middle-aged and elderly normal comparison subjects. All subjects were assessed with the Positive and Negative Syndrome Scale, Hamilton Rating Scale for Depression, modified Simpson-Angus Extrapyramidal Symptom Scale, the Abnormal Involuntary Movement Scale, and the Mattis Dementia Rating Scale (DRS). The two patient groups had similar levels of depressive symptoms, but the institutionalized patients had more severe positive and negative symptoms and were on higher doses of neuroleptic medication. The institutionalized patients had significantly more cognitive impairment on the DRS than outpatients and normal comparison subjects, particularly on the subscales of initiation/perseveration, conceptualization, and memory. Results are discussed in terms of the possible neuropathology associated with cognitive impairment in chronic schizophrenia.
J D Evans, and
A E Negron, and
B W Palmer, and
J S Paulsen, and
R K Heaton, and
D V Jeste
January 1997,
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry,
J D Evans, and
A E Negron, and
B W Palmer, and
J S Paulsen, and
R K Heaton, and
D V Jeste
October 2018,
Comprehensive psychiatry,
J D Evans, and
A E Negron, and
B W Palmer, and
J S Paulsen, and
R K Heaton, and
D V Jeste
January 2009,
Wiener klinische Wochenschrift,
J D Evans, and
A E Negron, and
B W Palmer, and
J S Paulsen, and
R K Heaton, and
D V Jeste
June 2001,
International journal of geriatric psychiatry,
J D Evans, and
A E Negron, and
B W Palmer, and
J S Paulsen, and
R K Heaton, and
D V Jeste
August 2003,
Journal of the American Geriatrics Society,
J D Evans, and
A E Negron, and
B W Palmer, and
J S Paulsen, and
R K Heaton, and
D V Jeste
October 2005,
Schizophrenia research,
J D Evans, and
A E Negron, and
B W Palmer, and
J S Paulsen, and
R K Heaton, and
D V Jeste
November 2022,
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
J D Evans, and
A E Negron, and
B W Palmer, and
J S Paulsen, and
R K Heaton, and
D V Jeste
January 2016,
Revista brasileira de enfermagem,
J D Evans, and
A E Negron, and
B W Palmer, and
J S Paulsen, and
R K Heaton, and
D V Jeste
June 2013,
Arquivos de neuro-psiquiatria,
J D Evans, and
A E Negron, and
B W Palmer, and
J S Paulsen, and
R K Heaton, and
D V Jeste
March 2001,
Journal of the Medical Association of Thailand = Chotmaihet thangphaet,
