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The structure and main features of a HF EM installation based upon a new approach for creating electromagnetic fields destined for whole body (WBH) and deep local (DLH) hyperthermia are discussed. The HF EM field, at a frequency of 13.56 MHz, is created by a coplanar capacity type applicator positioned under a distilled water filled bolus that the patient is lying on. The EM energy being released directly in the deep tissues ensures effective whole body heating to required therapeutic temperatures of up to 43.5 degrees C, whereas the skin temperature can be maintained as low as 39-40.5 degrees C. For DLH, the installation is equipped with additional applicators and a generator operating at a frequency of 40.68 MHz. High efficiency of the WBH applicator makes it possible to carry out the WBH procedure without any air-conditioning cabin. Due to this, a free access to the patient's body during the WBH treatment is provided and a simultaneous WBH/DLH or WBH/LH procedure by means of additional applicators is possible. Controllable power output in the range of 100-800 W at a frequency of 13.56 MHz and 50-350 W at a frequency of 40.68 MHz allows accurate temperature control during WBH, DLH and WBH/DLH procedures. SAR patterns created by the WBH and DLH applicators in a liquid muscle phantom and measured by means of a non-perturbing E-dipole are investigated. The scattered EM field strength measured in the vicinity of the operating installation during the WBH, DLH and WBH/DLH procedures does not exceed security standards. Examples of temperature versus time graphs in the course of WBH, DLH and WBH/DLH procedures in clinics are presented. The installation is successfully used in leading oncological institutions of Russia and Belarus, though combined WBH/DLH procedures are evidently more complicated and demand thorough planning and temperature measurements to avoid overheating.
V N Mazokhin, and
D N Kolmakov, and
N A Lucheyov, and
E A Gelvich, and
I I Troshin
June 2023,
Nature communications,
V N Mazokhin, and
D N Kolmakov, and
N A Lucheyov, and
E A Gelvich, and
I I Troshin
September 1977,
IEEE transactions on bio-medical engineering,
V N Mazokhin, and
D N Kolmakov, and
N A Lucheyov, and
E A Gelvich, and
I I Troshin
November 1995,
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association,
V N Mazokhin, and
D N Kolmakov, and
N A Lucheyov, and
E A Gelvich, and
I I Troshin
March 1996,
International journal of radiation oncology, biology, physics,
V N Mazokhin, and
D N Kolmakov, and
N A Lucheyov, and
E A Gelvich, and
I I Troshin
November 1999,
Deutsche medizinische Wochenschrift (1946),
V N Mazokhin, and
D N Kolmakov, and
N A Lucheyov, and
E A Gelvich, and
I I Troshin
September 1991,
Medical hypotheses,
V N Mazokhin, and
D N Kolmakov, and
N A Lucheyov, and
E A Gelvich, and
I I Troshin
January 1982,
Progress in clinical and biological research,
V N Mazokhin, and
D N Kolmakov, and
N A Lucheyov, and
E A Gelvich, and
I I Troshin
June 1976,
European journal of cancer,
V N Mazokhin, and
D N Kolmakov, and
N A Lucheyov, and
E A Gelvich, and
I I Troshin
January 1990,
Advances in experimental medicine and biology,
V N Mazokhin, and
D N Kolmakov, and
N A Lucheyov, and
E A Gelvich, and
I I Troshin
February 1970,
Die Medizinische Welt,
