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Geranylgeranylacetone (GGA) induces apoptosis in human leukemia HL-60 cells in a dose- and time-dependent manner. This effect was completely prevented by the pan-caspase inhibitor z-Val-Ala-Asp(OMe) fluoromethylketone, thereby implicating the caspase cascade in the process. Prior to DNA fragmentation, GGA treatment markedly activated caspase-3(-like) proteases, which might be responsible for the observed apoptosis. In addition, GGA treatment interfered with the processing and membrane localization of Rap1 and Ras, and these changes may be a result of apoptosis. Moreover, nitric oxide donors significantly accentuated the GGA-induced apoptosis, suggesting that the apoptotic pathway induced by GGA might be regulated by a redox-sensitive mechanism. Taken together, these data suggest that the isoprenoid, GGA, is an effective inducer of apoptotic cell death in HL-60 cells.
S Okada, and
M Yabuki, and
T Kanno, and
K Hamazaki, and
T Yoshioka, and
T Yasuda, and
A A Horton, and
K Utsumi
June 2006,
Journal of Asian natural products research,
S Okada, and
M Yabuki, and
T Kanno, and
K Hamazaki, and
T Yoshioka, and
T Yasuda, and
A A Horton, and
K Utsumi
January 2012,
Evidence-based complementary and alternative medicine : eCAM,
S Okada, and
M Yabuki, and
T Kanno, and
K Hamazaki, and
T Yoshioka, and
T Yasuda, and
A A Horton, and
K Utsumi
November 2011,
World journal of microbiology & biotechnology,
S Okada, and
M Yabuki, and
T Kanno, and
K Hamazaki, and
T Yoshioka, and
T Yasuda, and
A A Horton, and
K Utsumi
November 2001,
Acta pharmacologica Sinica,
S Okada, and
M Yabuki, and
T Kanno, and
K Hamazaki, and
T Yoshioka, and
T Yasuda, and
A A Horton, and
K Utsumi
September 1998,
Infection and immunity,
S Okada, and
M Yabuki, and
T Kanno, and
K Hamazaki, and
T Yoshioka, and
T Yasuda, and
A A Horton, and
K Utsumi
May 2018,
BMC cancer,
S Okada, and
M Yabuki, and
T Kanno, and
K Hamazaki, and
T Yoshioka, and
T Yasuda, and
A A Horton, and
K Utsumi
July 1997,
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi,
S Okada, and
M Yabuki, and
T Kanno, and
K Hamazaki, and
T Yoshioka, and
T Yasuda, and
A A Horton, and
K Utsumi
November 1993,
Leukemia,
S Okada, and
M Yabuki, and
T Kanno, and
K Hamazaki, and
T Yoshioka, and
T Yasuda, and
A A Horton, and
K Utsumi
December 1997,
Pharmacology & toxicology,
S Okada, and
M Yabuki, and
T Kanno, and
K Hamazaki, and
T Yoshioka, and
T Yasuda, and
A A Horton, and
K Utsumi
April 2001,
Carcinogenesis,
