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The effect of hypertonic mannitol on pressor responses to vasoactive agents was studied in isolated canine coronary arteries perfused with physiologic salt solution at a constant flow. When perfusion pressure was increased with 60 mM KCl, mannitol (50 mosM) consistently caused a decrease in perfusion pressure that lasted for at least 1 h. Withdrawal of mannitol from the perfusion media was associated with a vasoconstrictor response that was not prevented by alpha- or beta-adrenoceptor blockade or by the presence of either nitroglycerin or norepinephrine. Hypertonic mannitol also reduced the responsiveness of the isolated smooth muscle preparations to several different mechanistically unrelated vasodilator agents. The mechanism(s) responsible for the paradoxical ability of hypertonic mannitol to reduce vascular responsiveness to both vasoconstrictor and vasodilator interventions in isolated canine coronary arteries is not known, but future studies should be directed at elucidating it as well as determining whether similar phenomena occur in vivo.
V S Krishnamurty, and
H R Adams, and
G H Templeton, and
J T Willerson
September 1997,
Pharmacology,
V S Krishnamurty, and
H R Adams, and
G H Templeton, and
J T Willerson
March 1986,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
V S Krishnamurty, and
H R Adams, and
G H Templeton, and
J T Willerson
March 2006,
American journal of physiology. Heart and circulatory physiology,
V S Krishnamurty, and
H R Adams, and
G H Templeton, and
J T Willerson
January 1979,
Journal of cardiovascular pharmacology,
V S Krishnamurty, and
H R Adams, and
G H Templeton, and
J T Willerson
January 1988,
Proceedings of the Western Pharmacology Society,
V S Krishnamurty, and
H R Adams, and
G H Templeton, and
J T Willerson
September 1991,
Nihon Sanka Fujinka Gakkai zasshi,
V S Krishnamurty, and
H R Adams, and
G H Templeton, and
J T Willerson
February 1992,
British journal of anaesthesia,
V S Krishnamurty, and
H R Adams, and
G H Templeton, and
J T Willerson
January 1969,
Farmakologiia i toksikologiia,
V S Krishnamurty, and
H R Adams, and
G H Templeton, and
J T Willerson
April 1993,
Biulleten' eksperimental'noi biologii i meditsiny,
V S Krishnamurty, and
H R Adams, and
G H Templeton, and
J T Willerson
October 2001,
American journal of physiology. Regulatory, integrative and comparative physiology,
