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MIA was isolated previously as a small soluble protein secreted from malignant melanoma cell lines in vitro. Highly restricted expression patterns in melanocytic tumors were identified in vivo. We therefore quantitated serum levels of MIA protein by means of a non-radioactive ELISA and investigated whether MIA provides clinically relevant parameters in patients with malignant melanomas. Here we report enhanced MIA serum levels in 13% and 23% of patients with stage I and II disease, respectively, and in 100% with stage III or IV disease. Response to therapy in stage IV disease correlated with changes in MIA serum levels and surgical removal of metastases led to normalization of serum values. Repeated measuring of sera from 350 patients with a history of stage I or II melanoma during follow-up, we detected 32 patients developing positive MIA values. At the time of serum analysis 15 of them had developed metastases and one presented with metastatic disease 6 months later. In conclusion, MIA represents a novel serum marker for systemic malignant melanoma revealing the highest sensitivity and specificity among currently available markers.
A K Bosserhoff, and
M Lederer, and
M Kaufmann, and
R Hein, and
W Stolz, and
R Apfel, and
U Bogdahn, and
R Buettner
August 1997,
Cancer research,
A K Bosserhoff, and
M Lederer, and
M Kaufmann, and
R Hein, and
W Stolz, and
R Apfel, and
U Bogdahn, and
R Buettner
January 2001,
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer,
A K Bosserhoff, and
M Lederer, and
M Kaufmann, and
R Hein, and
W Stolz, and
R Apfel, and
U Bogdahn, and
R Buettner
January 2000,
Anticancer research,
A K Bosserhoff, and
M Lederer, and
M Kaufmann, and
R Hein, and
W Stolz, and
R Apfel, and
U Bogdahn, and
R Buettner
January 2000,
Anticancer research,
A K Bosserhoff, and
M Lederer, and
M Kaufmann, and
R Hein, and
W Stolz, and
R Apfel, and
U Bogdahn, and
R Buettner
February 1999,
Rheumatology (Oxford, England),
A K Bosserhoff, and
M Lederer, and
M Kaufmann, and
R Hein, and
W Stolz, and
R Apfel, and
U Bogdahn, and
R Buettner
April 2008,
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc,
A K Bosserhoff, and
M Lederer, and
M Kaufmann, and
R Hein, and
W Stolz, and
R Apfel, and
U Bogdahn, and
R Buettner
January 1995,
Journal of Tongji Medical University = Tong ji yi ke da xue xue bao,
A K Bosserhoff, and
M Lederer, and
M Kaufmann, and
R Hein, and
W Stolz, and
R Apfel, and
U Bogdahn, and
R Buettner
November 1994,
Cancer research,
A K Bosserhoff, and
M Lederer, and
M Kaufmann, and
R Hein, and
W Stolz, and
R Apfel, and
U Bogdahn, and
R Buettner
November 1989,
Journal of the National Cancer Institute,
A K Bosserhoff, and
M Lederer, and
M Kaufmann, and
R Hein, and
W Stolz, and
R Apfel, and
U Bogdahn, and
R Buettner
April 2013,
Histology and histopathology,
