BIOMAT Database Logo BIOMAT Database Logo

Synthesis and biological activity of 2',5'-oligoadenylate trimers containing 5'-terminal 5'-amino-5'-deoxy- and 5'-amino-3',5'-dideoxyadenosine derivatives. 1999

E I Kvasyuk, and I A Mikhailopulo, and R J Suhadolnik, and E E Henderson, and N F Muto, and K T Iacono, and J Homon, and W Pfleiderer
Institute of Bioorganic Chemistry, Byelorussian Academy of Sciences, Minsk, Belarus.

Some new 2',5'-oligonucleotide trimers containing 5'-terminal 5'-amino-5'-deoxy- and 5'-amino-3',5'-dideoxyadenosine derivatives have been synthesized. Some of the trimers showed biological inhibitions of HIV-1 reverse transcriptase (RT), HIV-1 induced syncytia formation and PCR amplification.

UI MeSH Term Description Entries
D009843 Oligoribonucleotides A group of ribonucleotides (up to 12) in which the phosphate residues of each ribonucleotide act as bridges in forming diester linkages between the ribose moieties.
D000227 Adenine Nucleotides Adenine Nucleotide,Adenosine Phosphate,Adenosine Phosphates,Nucleotide, Adenine,Nucleotides, Adenine,Phosphate, Adenosine,Phosphates, Adenosine
D001704 Biopolymers Polymers synthesized by living organisms. They play a role in the formation of macromolecular structures and are synthesized via the covalent linkage of biological molecules, especially AMINO ACIDS; NUCLEOTIDES; and CARBOHYDRATES. Bioplastics,Bioplastic,Biopolymer
D016048 Dideoxyadenosine A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is an inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal side effect is nephrotoxicity. In vivo, dideoxyadenosine is rapidly metabolized to DIDANOSINE (ddI) by enzymatic deamination; ddI is then converted to dideoxyinosine monophosphate and ultimately to dideoxyadenosine triphosphate, the putative active metabolite. 2',3'-Dideoxyadenosine,ddA (Antiviral),2',3' Dideoxyadenosine
D016133 Polymerase Chain Reaction In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships. Anchored PCR,Inverse PCR,Nested PCR,PCR,Anchored Polymerase Chain Reaction,Inverse Polymerase Chain Reaction,Nested Polymerase Chain Reaction,PCR, Anchored,PCR, Inverse,PCR, Nested,Polymerase Chain Reactions,Reaction, Polymerase Chain,Reactions, Polymerase Chain
D054303 HIV Reverse Transcriptase A reverse transcriptase encoded by the POL GENE of HIV. It is a heterodimer of 66 kDa and 51 kDa subunits that are derived from a common precursor protein. The heterodimer also includes an RNAse H activity (RIBONUCLEASE H, HUMAN IMMUNODEFICIENCY VIRUS) that plays an essential role the viral replication process. Reverse Transcriptase, HIV,Reverse Transcriptase, Human Immunodeficiency Virus,Transcriptase, HIV Reverse
D018894 Reverse Transcriptase Inhibitors Inhibitors of reverse transcriptase (RNA-DIRECTED DNA POLYMERASE), an enzyme that synthesizes DNA on an RNA template. Reverse Transcriptase Inhibitor,Inhibitors, Reverse Transcriptase,Inhibitor, Reverse Transcriptase,Transcriptase Inhibitor, Reverse
D019380 Anti-HIV Agents Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS. AIDS Drug,AIDS Drugs,Anti-AIDS Agents,Anti-AIDS Drug,Anti-HIV Agent,Anti-HIV Drug,Anti-AIDS Drugs,Anti-HIV Drugs,Agent, Anti-HIV,Agents, Anti-AIDS,Agents, Anti-HIV,Anti AIDS Agents,Anti AIDS Drug,Anti AIDS Drugs,Anti HIV Agent,Anti HIV Agents,Anti HIV Drug,Anti HIV Drugs,Drug, AIDS,Drug, Anti-AIDS,Drug, Anti-HIV,Drugs, AIDS,Drugs, Anti-AIDS,Drugs, Anti-HIV

Related Publications

E I Kvasyuk, and I A Mikhailopulo, and R J Suhadolnik, and E E Henderson, and N F Muto, and K T Iacono, and J Homon, and W Pfleiderer
Synthesis and biological activity of 2'-amino-2'-deoxy-5-fluorouridine.
April 1974, Journal of medicinal chemistry,
E I Kvasyuk, and I A Mikhailopulo, and R J Suhadolnik, and E E Henderson, and N F Muto, and K T Iacono, and J Homon, and W Pfleiderer
Synthesis and biological activity of 3- and 5-amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone.
June 1996, Journal of medicinal chemistry,
E I Kvasyuk, and I A Mikhailopulo, and R J Suhadolnik, and E E Henderson, and N F Muto, and K T Iacono, and J Homon, and W Pfleiderer
[Acyclic nucleoside analogs: synthesis and cytotoxic properties of acyl derivatives of 3'(5')-amino-3'(5')-deoxy-2',3'-secoadenosine].
August 1995, Bioorganicheskaia khimiia,
E I Kvasyuk, and I A Mikhailopulo, and R J Suhadolnik, and E E Henderson, and N F Muto, and K T Iacono, and J Homon, and W Pfleiderer
Synthesis and properties of oligonucleotide chimeras containing 5'-amino-2'-deoxy-2'-fluoroarabinonucleosides.
January 2003, Nucleosides, nucleotides & nucleic acids,
E I Kvasyuk, and I A Mikhailopulo, and R J Suhadolnik, and E E Henderson, and N F Muto, and K T Iacono, and J Homon, and W Pfleiderer
2',3'=Carbonates in the synthesis of uridine 5'-deoxy and 2',5'-dideoxy derivatives.
April 1976, Nucleic acids research,
E I Kvasyuk, and I A Mikhailopulo, and R J Suhadolnik, and E E Henderson, and N F Muto, and K T Iacono, and J Homon, and W Pfleiderer
Synthesis and biological evaluation of some 5-nitro- and 5-amino derivatives of 2'-deoxycytidine, 2',3'-dideoxyuridine, and 2',3'-dideoxycytidine.
November 2003, Nucleosides, nucleotides & nucleic acids,
E I Kvasyuk, and I A Mikhailopulo, and R J Suhadolnik, and E E Henderson, and N F Muto, and K T Iacono, and J Homon, and W Pfleiderer
Diosgenyl 2-amino-2-deoxy-β-D-galactopyranoside: synthesis, derivatives and antimicrobial activity.
January 2017, Beilstein journal of organic chemistry,
E I Kvasyuk, and I A Mikhailopulo, and R J Suhadolnik, and E E Henderson, and N F Muto, and K T Iacono, and J Homon, and W Pfleiderer
Synthesis and biological properties of 2'-deoxy-5-vinyluridine and 2'deoxy-5-vinylcytidine.
September 1982, Nucleic acids research,
E I Kvasyuk, and I A Mikhailopulo, and R J Suhadolnik, and E E Henderson, and N F Muto, and K T Iacono, and J Homon, and W Pfleiderer
Synthesis and Antioxidant Activity of 2-Amino-5-methylthiazol Derivatives Containing 1,3,4-Oxadiazole-2-thiol Moiety.
January 2013, ISRN organic chemistry,
E I Kvasyuk, and I A Mikhailopulo, and R J Suhadolnik, and E E Henderson, and N F Muto, and K T Iacono, and J Homon, and W Pfleiderer
Synthesis and biological activity of 3'-hydroxy-5'-aminobenzoxazinorifamycin derivatives.
January 1993, Chemical & pharmaceutical bulletin,
Copied contents to your clipboard!