-transparent.png){kind=logo}
The hepatocarcinogenicity of 2-methyl-N,N-dimethyl-4-aminoazobenzene, previously shown to be noncarcinogenic in adult rats in the absence of further treatment, was observed by following a 1- to 6-week period of feeding this dye to weanling rats with the dietary administration of 0.05% phenobarbital for up to 70 weeks. Many large hepatocellular carcinomas developed in the phenobarbital-treated animals by 72 weeks, whereas a very small number of tiny neoplastic nodules, including one carcinoma, were seen in the rats not given this drug. This study suggests that the use of promoting agents, following the short-term administration of weak carcinogens for the liver, can be useful in demonstrating the initiating activity of such compounds. This system may be useful in the identification of such agents in the environment.
T Kitagawa, and
H C Pitot, and
E C Miller, and
J A Miller
July 1970,
Cancer research,
T Kitagawa, and
H C Pitot, and
E C Miller, and
J A Miller
October 1983,
Cancer research,
T Kitagawa, and
H C Pitot, and
E C Miller, and
J A Miller
January 1983,
Neoplasma,
T Kitagawa, and
H C Pitot, and
E C Miller, and
J A Miller
August 1975,
Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association,
T Kitagawa, and
H C Pitot, and
E C Miller, and
J A Miller
January 1987,
Drug metabolism and disposition: the biological fate of chemicals,
T Kitagawa, and
H C Pitot, and
E C Miller, and
J A Miller
December 1991,
Gan to kagaku ryoho. Cancer & chemotherapy,
T Kitagawa, and
H C Pitot, and
E C Miller, and
J A Miller
July 1991,
Xenobiotica; the fate of foreign compounds in biological systems,
T Kitagawa, and
H C Pitot, and
E C Miller, and
J A Miller
July 1981,
Biochimica et biophysica acta,
T Kitagawa, and
H C Pitot, and
E C Miller, and
J A Miller
May 1980,
Carcinogenesis,
T Kitagawa, and
H C Pitot, and
E C Miller, and
J A Miller
December 1981,
National Cancer Institute monograph,
