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Mutations at codons 12, 13, or 61 of the H-ras, K-ras, and N-ras have been detected in human neoplasias by a variety of techniques. Some of these techniques are very sensitive and can detect K-ras mutation in 90% of the cases of pancreatic adenocarcinomas. We analyzed 11 samples of pancreatic adenocarcinoma, three samples of pancreatic mucinous cystadenoma, and two samples without tumors in formalin-fixed paraffin embedded tissue sections. K-ras mutations at codon 12 were detected by a two-step PCR-enriched technique in all the samples of pancreatic adenocarcinoma, but not in cystadenoma or control samples. This technique may be useful for early detection of pancreatic cancer.
M S Kubrusly, and
E Matheucci Júnior, and
K R Leite, and
A M Coelho, and
O Monte, and
M C Machado, and
H W Pinotti
March 2004,
World journal of gastroenterology,
M S Kubrusly, and
E Matheucci Júnior, and
K R Leite, and
A M Coelho, and
O Monte, and
M C Machado, and
H W Pinotti
May 2003,
Hepatobiliary & pancreatic diseases international : HBPD INT,
M S Kubrusly, and
E Matheucci Júnior, and
K R Leite, and
A M Coelho, and
O Monte, and
M C Machado, and
H W Pinotti
October 1994,
Gastroenterology,
M S Kubrusly, and
E Matheucci Júnior, and
K R Leite, and
A M Coelho, and
O Monte, and
M C Machado, and
H W Pinotti
March 1994,
Cancer,
M S Kubrusly, and
E Matheucci Júnior, and
K R Leite, and
A M Coelho, and
O Monte, and
M C Machado, and
H W Pinotti
February 2004,
World journal of gastroenterology,
M S Kubrusly, and
E Matheucci Júnior, and
K R Leite, and
A M Coelho, and
O Monte, and
M C Machado, and
H W Pinotti
October 1993,
Environmental health perspectives,
M S Kubrusly, and
E Matheucci Júnior, and
K R Leite, and
A M Coelho, and
O Monte, and
M C Machado, and
H W Pinotti
September 2002,
JOP : Journal of the pancreas,
M S Kubrusly, and
E Matheucci Júnior, and
K R Leite, and
A M Coelho, and
O Monte, and
M C Machado, and
H W Pinotti
November 1991,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
M S Kubrusly, and
E Matheucci Júnior, and
K R Leite, and
A M Coelho, and
O Monte, and
M C Machado, and
H W Pinotti
January 1995,
Annales de biologie clinique,
M S Kubrusly, and
E Matheucci Júnior, and
K R Leite, and
A M Coelho, and
O Monte, and
M C Machado, and
H W Pinotti
January 1999,
Hepato-gastroenterology,
