-transparent.png){kind=logo}
BACKGROUND Genetic and environmental factors are known to play a role in the development of atopic diseases, such as asthma, eczema, and rhinitis. However, the atopy gene (or genes) has yet to be defined. Studies of familial asthma have identified several regions that may contain genes predisposing to atopy, but the data for candidate regions do not show agreement, which may be due to heterogeneity, ascertainment bias, or stochastic factors. Factors such as an early age of onset, a positive family history, and a clearly defined phenotype favor a genetic origin and improve the chance of identifying genes that predispose to atopy. OBJECTIVE We sought to define genes that predispose to the development of atopic eczema. METHODS We have studied nuclear families with multiple cases of early-onset atopic eczema for involvement of the candidate regions on chromosomes 5q31 (IL gene cluster), 11q13 (high-affinity FCepsilon receptor), 14q11.2 (mast cell chymase), and 16p12 (IL-4 receptor alpha-chain, IL4RA gene). RESULTS Using a recessive model, we find a maximum parametric log of the odds of linkage score of 2. 25 and nonparametric score of 2.54 (P =.006) for a region on chromosome 5q31, which we postulate contains a gene predisposing to atopic eczema, but lack of support for linkage to 11q13. Transmission disequilibrium tests do not support an association with candidate polymorphisms in the mast cell chymase and IL4RA genes. CONCLUSIONS We have identified a clinically homogeneous cohort of patients with atopic eczema to identify genetic factors predisposing to the development of atopy. We postulate that there are certain loci that predispose to atopy in general and other loci that determine which of the atopic phenotypes is expressed.
S Forrest, and
K Dunn, and
K Elliott, and
E Fitzpatrick, and
J Fullerton, and
M McCarthy, and
J Brown, and
D Hill, and
R Williamson
August 1996,
Lancet (London, England),
S Forrest, and
K Dunn, and
K Elliott, and
E Fitzpatrick, and
J Fullerton, and
M McCarthy, and
J Brown, and
D Hill, and
R Williamson
January 1965,
Bulletin de la Societe francaise de dermatologie et de syphiligraphie,
S Forrest, and
K Dunn, and
K Elliott, and
E Fitzpatrick, and
J Fullerton, and
M McCarthy, and
J Brown, and
D Hill, and
R Williamson
March 1999,
Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege,
S Forrest, and
K Dunn, and
K Elliott, and
E Fitzpatrick, and
J Fullerton, and
M McCarthy, and
J Brown, and
D Hill, and
R Williamson
June 1946,
Archives of dermatology and syphilology,
S Forrest, and
K Dunn, and
K Elliott, and
E Fitzpatrick, and
J Fullerton, and
M McCarthy, and
J Brown, and
D Hill, and
R Williamson
January 2014,
Chemical immunology and allergy,
S Forrest, and
K Dunn, and
K Elliott, and
E Fitzpatrick, and
J Fullerton, and
M McCarthy, and
J Brown, and
D Hill, and
R Williamson
August 1994,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
S Forrest, and
K Dunn, and
K Elliott, and
E Fitzpatrick, and
J Fullerton, and
M McCarthy, and
J Brown, and
D Hill, and
R Williamson
February 1993,
The Practitioner,
S Forrest, and
K Dunn, and
K Elliott, and
E Fitzpatrick, and
J Fullerton, and
M McCarthy, and
J Brown, and
D Hill, and
R Williamson
May 1951,
The Journal of the American Osteopathic Association,
S Forrest, and
K Dunn, and
K Elliott, and
E Fitzpatrick, and
J Fullerton, and
M McCarthy, and
J Brown, and
D Hill, and
R Williamson
March 2006,
Community practitioner : the journal of the Community Practitioners' & Health Visitors' Association,
S Forrest, and
K Dunn, and
K Elliott, and
E Fitzpatrick, and
J Fullerton, and
M McCarthy, and
J Brown, and
D Hill, and
R Williamson
September 1955,
The Medical journal of Australia,
