BIOMAT Database Logo BIOMAT Database Logo

Influence of obesity and body fat distribution on growth hormone kinetics in humans. 1999

J G Langendonk, and A E Meinders, and J Burggraaf, and M Frölich, and C A Roelen, and R C Schoemaker, and A F Cohen, and H Pijl
Department of General Internal Medicine, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.

We studied the kinetics of exogenous recombinant 22-kDa human growth hormone (rhGH) in premenopausal women with upper body obesity (UBO), lower body obesity (LBO), or normal body weight. A bolus of 100 mU rhGH was administered during a continuous infusion of somatostatin to suppress endogenous GH secretion. GH kinetics were investigated with noncompartmental analysis of plasma GH curves. GH peak values in response to GH infusion and plasma half-life of GH were not significantly different between normal weight and obese subjects. In contrast, GH clearance was 33% higher in LBO women and 51% higher in UBO women compared with clearance in normal weight controls. The difference in clearance between LBO and UBO was not statistically significant. Altered GH clearance characteristics contribute to low circulating GH levels in obese humans. Body fat distribution does not appear to affect GH kinetics.

UI MeSH Term Description Entries
D007275 Injections, Intravenous Injections made into a vein for therapeutic or experimental purposes. Intravenous Injections,Injection, Intravenous,Intravenous Injection
D009765 Obesity A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000273 Adipose Tissue Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white. Fatty Tissue,Body Fat,Fat Pad,Fat Pads,Pad, Fat,Pads, Fat,Tissue, Adipose,Tissue, Fatty
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D013004 Somatostatin A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal. Cyclic Somatostatin,Somatostatin-14,Somatotropin Release-Inhibiting Hormone,SRIH-14,Somatofalk,Somatostatin, Cyclic,Somatotropin Release-Inhibiting Factor,Stilamin,Somatostatin 14,Somatotropin Release Inhibiting Factor,Somatotropin Release Inhibiting Hormone
D013006 Growth Hormone A polypeptide that is secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Growth hormone, also known as somatotropin, stimulates mitosis, cell differentiation and cell growth. Species-specific growth hormones have been synthesized. Growth Hormone, Recombinant,Pituitary Growth Hormone,Recombinant Growth Hormone,Somatotropin,Somatotropin, Recombinant,Growth Hormone, Pituitary,Growth Hormones Pituitary, Recombinant,Pituitary Growth Hormones, Recombinant,Recombinant Growth Hormones,Recombinant Pituitary Growth Hormones,Recombinant Somatotropins,Somatotropins, Recombinant,Growth Hormones, Recombinant,Recombinant Somatotropin
D015992 Body Mass Index An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI Quetelet Index,Quetelet's Index,Index, Body Mass,Index, Quetelet,Quetelets Index
D017097 Electric Impedance The resistance to the flow of either alternating or direct electrical current. Bioelectrical Impedance,Electric Resistance,Impedance,Ohmic Resistance,Biolectric Impedance,Electrical Impedance,Electrical Resistance,Impedance, Bioelectrical,Impedance, Biolectric,Impedance, Electric,Impedance, Electrical,Ohmic Resistances,Resistance, Electric,Resistance, Electrical,Resistance, Ohmic,Resistances, Ohmic

Related Publications

J G Langendonk, and A E Meinders, and J Burggraaf, and M Frölich, and C A Roelen, and R C Schoemaker, and A F Cohen, and H Pijl
Glucose metabolism in obesity: influence of body fat distribution.
October 1988, The Journal of clinical endocrinology and metabolism,
J G Langendonk, and A E Meinders, and J Burggraaf, and M Frölich, and C A Roelen, and R C Schoemaker, and A F Cohen, and H Pijl
Influence of body fat distribution on free fatty acid metabolism in obesity.
April 1989, The Journal of clinical investigation,
J G Langendonk, and A E Meinders, and J Burggraaf, and M Frölich, and C A Roelen, and R C Schoemaker, and A F Cohen, and H Pijl
Splanchnic insulin metabolism in obesity. Influence of body fat distribution.
December 1986, The Journal of clinical investigation,
J G Langendonk, and A E Meinders, and J Burggraaf, and M Frölich, and C A Roelen, and R C Schoemaker, and A F Cohen, and H Pijl
Obesity and beta-blockers: influence of body fat on their kinetics and cardiovascular effects.
March 1989, Journal of clinical pharmacology,
J G Langendonk, and A E Meinders, and J Burggraaf, and M Frölich, and C A Roelen, and R C Schoemaker, and A F Cohen, and H Pijl
Relationship of obesity to diabetes: influence of obesity level and body fat distribution.
March 1983, Preventive medicine,
J G Langendonk, and A E Meinders, and J Burggraaf, and M Frölich, and C A Roelen, and R C Schoemaker, and A F Cohen, and H Pijl
Effects of growth hormone on fat mass and fat distribution.
September 1992, Acta paediatrica (Oslo, Norway : 1992). Supplement,
J G Langendonk, and A E Meinders, and J Burggraaf, and M Frölich, and C A Roelen, and R C Schoemaker, and A F Cohen, and H Pijl
Measuring body fat distribution and content in humans.
September 2002, Current opinion in clinical nutrition and metabolic care,
J G Langendonk, and A E Meinders, and J Burggraaf, and M Frölich, and C A Roelen, and R C Schoemaker, and A F Cohen, and H Pijl
Alterations in body composition and fat distribution in growth hormone-deficient prepubertal children during growth hormone therapy.
May 2001, Metabolism: clinical and experimental,
J G Langendonk, and A E Meinders, and J Burggraaf, and M Frölich, and C A Roelen, and R C Schoemaker, and A F Cohen, and H Pijl
Growth hormone actions on fat distribution and metabolism.
January 1992, Hormone research,
J G Langendonk, and A E Meinders, and J Burggraaf, and M Frölich, and C A Roelen, and R C Schoemaker, and A F Cohen, and H Pijl
Endometrial cancer, obesity, and body fat distribution.
January 1991, Cancer research,
Copied contents to your clipboard!