BIOMAT Database Logo BIOMAT Database Logo

Specific lipopolysaccharide found in cystic fibrosis airway Pseudomonas aeruginosa. 1999

R K Ernst, and E C Yi, and L Guo, and K B Lim, and J L Burns, and M Hackett, and S I Miller
Department of Medicine, University of Washington, Seattle, WA 98195, USA.

Cystic fibrosis (CF) patients develop chronic airway infections with Pseudomonas aeruginosa (PA). Pseudomonas aeruginosa synthesized lipopolysaccharide (LPS) with a variety of penta- and hexa-acylated lipid A structures under different environmental conditions. CF patient PA synthesized LPS with specific lipid A structures indicating unique recognition of the CF airway environment. CF-specific lipid A forms containing palmitate and aminoarabinose were associated with resistance to cationic antimicrobial peptides and increased inflammatory responses, indicating that they are likely to be involved in airway disease.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D008050 Lipid A Lipid A is the biologically active component of lipopolysaccharides. It shows strong endotoxic activity and exhibits immunogenic properties.
D008070 Lipopolysaccharides Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed) Lipopolysaccharide,Lipoglycans
D008274 Magnesium A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
D009154 Mutation Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. Mutations
D010168 Palmitates Salts and esters of the 16-carbon saturated monocarboxylic acid--palmitic acid. Hexadecanoates,Palmitate
D010455 Peptides Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are considered to be larger versions of peptides that can form into complex structures such as ENZYMES and RECEPTORS. Peptide,Polypeptide,Polypeptides
D011113 Polymyxins Basic lipopeptide antibiotic group obtained from Bacillus polymyxa. They affect the cell membrane by detergent action and may cause neuromuscular and kidney damage. At least eleven different members of the polymyxin group have been identified, each designated by a letter. Polymyxin,Polymyxin M
D011550 Pseudomonas aeruginosa A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection. Bacillus aeruginosus,Bacillus pyocyaneus,Bacterium aeruginosum,Bacterium pyocyaneum,Micrococcus pyocyaneus,Pseudomonas polycolor,Pseudomonas pyocyanea
D011552 Pseudomonas Infections Infections with bacteria of the genus PSEUDOMONAS. Infections, Pseudomonas,Pseudomonas aeruginosa Infection,Infection, Pseudomonas,Pseudomonas Infection,Pseudomonas aeruginosa Infections

Related Publications

R K Ernst, and E C Yi, and L Guo, and K B Lim, and J L Burns, and M Hackett, and S I Miller
Pseudomonas aeruginosa biofilm formation in the cystic fibrosis airway.
August 2008, Pulmonary pharmacology & therapeutics,
R K Ernst, and E C Yi, and L Guo, and K B Lim, and J L Burns, and M Hackett, and S I Miller
Pseudomonas aeruginosa exotoxin pyocyanin causes cystic fibrosis airway pathogenesis.
December 2009, The American journal of pathology,
R K Ernst, and E C Yi, and L Guo, and K B Lim, and J L Burns, and M Hackett, and S I Miller
The role of Pseudomonas lipopolysaccharide in cystic fibrosis airway infection.
January 2010, Sub-cellular biochemistry,
R K Ernst, and E C Yi, and L Guo, and K B Lim, and J L Burns, and M Hackett, and S I Miller
Airway epithelial control of Pseudomonas aeruginosa infection in cystic fibrosis.
March 2008, Trends in molecular medicine,
R K Ernst, and E C Yi, and L Guo, and K B Lim, and J L Burns, and M Hackett, and S I Miller
Inhaled aztreonam lysine for chronic airway Pseudomonas aeruginosa in cystic fibrosis.
November 2008, American journal of respiratory and critical care medicine,
R K Ernst, and E C Yi, and L Guo, and K B Lim, and J L Burns, and M Hackett, and S I Miller
[Chronic Pseudomonas aeruginosa airway colonization in cystic fibrosis patients : Prevention concepts].
November 2017, Der Internist,
R K Ernst, and E C Yi, and L Guo, and K B Lim, and J L Burns, and M Hackett, and S I Miller
Molecular epidemiology of chronic Pseudomonas aeruginosa airway infections in cystic fibrosis.
January 2012, PloS one,
R K Ernst, and E C Yi, and L Guo, and K B Lim, and J L Burns, and M Hackett, and S I Miller
Emergence and persistence of Pseudomonas aeruginosa in the cystic fibrosis airway.
September 1992, Seminars in respiratory infections,
R K Ernst, and E C Yi, and L Guo, and K B Lim, and J L Burns, and M Hackett, and S I Miller
Immunoglobulin-G subclasses in cystic fibrosis. IgG2 response to Pseudomonas aeruginosa lipopolysaccharide.
March 1986, The American review of respiratory disease,
R K Ernst, and E C Yi, and L Guo, and K B Lim, and J L Burns, and M Hackett, and S I Miller
Cystic fibrosis. Pseudomonas aeruginosa infection.
March 2006, The Ceylon medical journal,
Copied contents to your clipboard!