BIOMAT Database Logo BIOMAT Database Logo

Anabolic effects of insulin-like growth factor in combination with insulin-like growth factor binding protein-3 in severely burned adults. 1999

M A Debroy, and S E Wolf, and X J Zhang, and D L Chinkes, and A A Ferrando, and R R Wolfe, and D N Herndon
Shriners Hospitals for Children, Galveston, Texas 77550, USA.

BACKGROUND The purpose of this study was to determine the anabolic effects of recombinant human insulin-like growth factor-I (rhIGF-1) complexed with its principal binding protein IGF-1 binding protein-3 (IGFBP-3) in severely burned adults. METHODS Ten burned adults were studied consecutively after receiving saline (pretreatment), then rhIGF-1/IGFBP-3 (treatment) for 5 days. Doses were 1, 2, and 4 mg/kg per day. Glucose, electrolytes, hormones, and leg muscle protein metabolism were determined. Nine other studies were performed on similarly injured adults at comparable times to the treatment studies to control for time effects. RESULTS Serum IGF-1 and IGFBP-3 levels increased with all doses, but no incremental increases were found. Leg protein balance improved with rhIGF-1/IGFBP-3, which was associated with an increase in muscle protein fractional synthetic rate. These effects were independent of time. All patients were euglycemic without electrolyte imbalances. CONCLUSIONS Net protein synthesis in the isolated leg of severely burned adults improved with rhIGF-1/IGFBP-3 without development of glucose abnormalities.

UI MeSH Term Description Entries
D007334 Insulin-Like Growth Factor I A well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and mitogenic activities. This growth factor has a major, but not absolute, dependence on GROWTH HORMONE. It is believed to be mainly active in adults in contrast to INSULIN-LIKE GROWTH FACTOR II, which is a major fetal growth factor. IGF-I,Somatomedin C,IGF-1,IGF-I-SmC,Insulin Like Growth Factor I,Insulin-Like Somatomedin Peptide I,Insulin Like Somatomedin Peptide I
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009124 Muscle Proteins The protein constituents of muscle, the major ones being ACTINS and MYOSINS. More than a dozen accessory proteins exist including TROPONIN; TROPOMYOSIN; and DYSTROPHIN. Muscle Protein,Protein, Muscle,Proteins, Muscle
D011994 Recombinant Proteins Proteins prepared by recombinant DNA technology. Biosynthetic Protein,Biosynthetic Proteins,DNA Recombinant Proteins,Recombinant Protein,Proteins, Biosynthetic,Proteins, Recombinant DNA,DNA Proteins, Recombinant,Protein, Biosynthetic,Protein, Recombinant,Proteins, DNA Recombinant,Proteins, Recombinant,Recombinant DNA Proteins,Recombinant Proteins, DNA
D002056 Burns Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like. Burn
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004334 Drug Administration Schedule Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience. Administration Schedule, Drug,Administration Schedules, Drug,Drug Administration Schedules,Schedule, Drug Administration,Schedules, Drug Administration
D004734 Energy Metabolism The chemical reactions involved in the production and utilization of various forms of energy in cells. Bioenergetics,Energy Expenditure,Bioenergetic,Energy Expenditures,Energy Metabolisms,Expenditure, Energy,Expenditures, Energy,Metabolism, Energy,Metabolisms, Energy
D005260 Female Females

Related Publications

M A Debroy, and S E Wolf, and X J Zhang, and D L Chinkes, and A A Ferrando, and R R Wolfe, and D N Herndon
High-affinity growth hormone binding protein, insulin-like growth factor I and insulin-like growth factor binding protein 3 in adults with growth hormone deficiency.
July 1996, European journal of endocrinology,
M A Debroy, and S E Wolf, and X J Zhang, and D L Chinkes, and A A Ferrando, and R R Wolfe, and D N Herndon
Modulation of types I and II acute phase reactants with insulin-like growth factor-1/binding protein-3 complex in severely burned children.
January 2002, Critical care medicine,
M A Debroy, and S E Wolf, and X J Zhang, and D L Chinkes, and A A Ferrando, and R R Wolfe, and D N Herndon
Modulation of types I and II acute phase reactants with insulin-like growth factor-1/binding protein-3 complex in severely burned children.
January 2002, Critical care medicine,
M A Debroy, and S E Wolf, and X J Zhang, and D L Chinkes, and A A Ferrando, and R R Wolfe, and D N Herndon
Somatomedin-1 binding protein-3: insulin-like growth factor-1 binding protein-3, insulin-like growth factor-1 carrier protein.
January 2003, BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy,
M A Debroy, and S E Wolf, and X J Zhang, and D L Chinkes, and A A Ferrando, and R R Wolfe, and D N Herndon
Insulin-like growth factor-binding protein 1 and insulin-like growth factor-binding protein 3 in pre-eclampsia.
July 1996, British journal of obstetrics and gynaecology,
M A Debroy, and S E Wolf, and X J Zhang, and D L Chinkes, and A A Ferrando, and R R Wolfe, and D N Herndon
In silico interaction of insulin-like growth factor binding protein 3 with insulin-like growth factor 1.
August 2018, Research in pharmaceutical sciences,
M A Debroy, and S E Wolf, and X J Zhang, and D L Chinkes, and A A Ferrando, and R R Wolfe, and D N Herndon
[Insulin-like growth factor binding protein-3 (IGFBP-3)].
December 1999, Nihon rinsho. Japanese journal of clinical medicine,
M A Debroy, and S E Wolf, and X J Zhang, and D L Chinkes, and A A Ferrando, and R R Wolfe, and D N Herndon
[Insulin-like growth factor binding protein-3 (IGFBP-3)].
August 2005, Nihon rinsho. Japanese journal of clinical medicine,
M A Debroy, and S E Wolf, and X J Zhang, and D L Chinkes, and A A Ferrando, and R R Wolfe, and D N Herndon
Insulin-like growth factor binding-protein-3 (IGFBP-3).
October 2015, Best practice & research. Clinical endocrinology & metabolism,
M A Debroy, and S E Wolf, and X J Zhang, and D L Chinkes, and A A Ferrando, and R R Wolfe, and D N Herndon
Insulin-like growth factor binding protein-3: insulin-like growth factor independence comes of age.
May 2006, Endocrinology,
Copied contents to your clipboard!