Biomaterial Database

Amyloidosis, macroglossia, and carpal tunnel syndrome associated with myeloma. 1975

R K Akin, and K Baron, and P J Walters

A case report of a patient with amyloidosis presented in which macroglossia and bilateral carpal tunnel syndrome were the initial features and myeloma was the probable underlying cause.

UI	MeSH Term	Description	Entries
D008260	Macroglossia	The presence of an excessively large tongue, which may be congenital or may develop as a result of a tumor or edema due to obstruction of lymphatic vessels, or it may occur in association with hyperpituitarism or acromegaly. It also may be associated with malocclusion because of pressure of the tongue on the teeth. (From Jablonski, Dictionary of Dentistry, 1992)	Macroglossias
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009101	Multiple Myeloma	A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.	Myeloma, Plasma-Cell,Kahler Disease,Myeloma, Multiple,Myeloma-Multiple,Myelomatosis,Plasma Cell Myeloma,Cell Myeloma, Plasma,Cell Myelomas, Plasma,Disease, Kahler,Multiple Myelomas,Myeloma Multiple,Myeloma, Plasma Cell,Myeloma-Multiples,Myelomas, Multiple,Myelomas, Plasma Cell,Myelomas, Plasma-Cell,Myelomatoses,Plasma Cell Myelomas,Plasma-Cell Myeloma,Plasma-Cell Myelomas
D002349	Carpal Tunnel Syndrome	Entrapment of the MEDIAN NERVE in the carpal tunnel, which is formed by the flexor retinaculum and the CARPAL BONES. This syndrome may be associated with repetitive occupational trauma (CUMULATIVE TRAUMA DISORDERS); wrist injuries; AMYLOID NEUROPATHIES; rheumatoid arthritis (see ARTHRITIS, RHEUMATOID); ACROMEGALY; PREGNANCY; and other conditions. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. (Joynt, Clinical Neurology, 1995, Ch51, p45)	Compression Neuropathy, Carpal Tunnel,Entrapment Neuropathy, Carpal Tunnel,Amyotrophy, Thenar, Of Carpal Origin,Median Neuropathy, Carpal Tunnel,Carpal Tunnel Syndromes,Syndrome, Carpal Tunnel,Syndromes, Carpal Tunnel
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000686	Amyloidosis	A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.	Amyloidoses
D012447	Sacrum	Five fused VERTEBRAE forming a triangle-shaped structure at the back of the PELVIS. It articulates superiorly with the LUMBAR VERTEBRAE, inferiorly with the COCCYX, and anteriorly with the ILIUM of the PELVIS. The sacrum strengthens and stabilizes the PELVIS.	Sacra,Sacral Vertebra,Sacral Vertebrae,Sacrums,Vertebra, Sacral,Vertebrae, Sacral
D013125	Spinal Neoplasms	New abnormal growth of tissue in the SPINE.	Neoplasm, Spinal,Neoplasms, Spinal,Spinal Neoplasm
D014059	Tongue	A muscular organ in the mouth that is covered with pink tissue called mucosa, tiny bumps called papillae, and thousands of taste buds. The tongue is anchored to the mouth and is vital for chewing, swallowing, and for speech.	Tongues

Related Publications

R K Akin, and K Baron, and P J Walters

Para-amyloidosis, macroglossia and carpal-tunnel syndrome with myeloma.

May 1968, German medical monthly,

R K Akin, and K Baron, and P J Walters

Macroglossia and carpal tunnel syndrome associated with multiple myeloma: a case report.

January 2005, Irish journal of medical science,

R K Akin, and K Baron, and P J Walters

[A case of multiple myeloma complicated with amyloidosis and carpal tunnel syndrome].

November 1984, [Rinsho ketsueki] The Japanese journal of clinical hematology,

R K Akin, and K Baron, and P J Walters

Amyloidosis and carpal-tunnel syndrome.

June 1970, The New England journal of medicine,

R K Akin, and K Baron, and P J Walters

Carpal tunnel syndrome and amyloidosis associated with continuous ambulatory peritoneal dialysis.

October 1988, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne,

R K Akin, and K Baron, and P J Walters

[Carpal tunnel syndrome and ATTR-amyloidosis].

September 2018, Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V...,

R K Akin, and K Baron, and P J Walters

Amyloidosis and the carpal tunnel syndrome.

May 1974, American journal of clinical pathology,

R K Akin, and K Baron, and P J Walters

Massive macroglossia, amyloidosis and myeloma.

September 1988, Postgraduate medical journal,

R K Akin, and K Baron, and P J Walters

Carpal tunnel syndrome due to amyloidosis.

January 2021, Postgraduate medical journal,

R K Akin, and K Baron, and P J Walters

Hereditary transthyretin amyloidosis presenting with carpal tunnel syndrome.

January 2024, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne,