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We have developed general methods for the synthesis of 4'-fluoro- and 4'-methoxynucleosides by addition of iodinemonofluoride or iodine and methanol across the double bond of suitably protected 4',5'-unsaturated pyrimidine and purine nucleosides. The structures of these adducts have been determined by a combination of chemical, spectroscopic, and electrophoretic methods. The 4'-methoxy- and the uridine analogs of nucleocidin have been synthesized from the corresponding 4'-fluorouridine and 4'-methoxyadenosine derivatives.
Related Publications
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I D Jenkins, and
G R Owen, and
S D Dimitrijevich, and
C M Richards, and
P C Srivastava, and
N Le-Hong, and
J G Moffatt
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Journal of medicinal chemistry,
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I D Jenkins, and
G R Owen, and
S D Dimitrijevich, and
C M Richards, and
P C Srivastava, and
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J G Moffatt
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The Journal of organic chemistry,
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P C Srivastava, and
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Journal of medicinal chemistry,
J P Verheyden, and
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P C Srivastava, and
N Le-Hong, and
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Polish journal of pharmacology and pharmacy,
J P Verheyden, and
I D Jenkins, and
G R Owen, and
S D Dimitrijevich, and
C M Richards, and
P C Srivastava, and
N Le-Hong, and
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The Journal of organic chemistry,
J P Verheyden, and
I D Jenkins, and
G R Owen, and
S D Dimitrijevich, and
C M Richards, and
P C Srivastava, and
N Le-Hong, and
J G Moffatt
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Journal of medicinal chemistry,
J P Verheyden, and
I D Jenkins, and
G R Owen, and
S D Dimitrijevich, and
C M Richards, and
P C Srivastava, and
N Le-Hong, and
J G Moffatt
January 1965,
Chemical & pharmaceutical bulletin,
J P Verheyden, and
I D Jenkins, and
G R Owen, and
S D Dimitrijevich, and
C M Richards, and
P C Srivastava, and
N Le-Hong, and
J G Moffatt
January 1981,
Nucleic acids symposium series,
