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Experiments were conducted to evaluate the possibility that central GABA(A) receptors are involved in the stress response of rats. Separate groups of animals were implanted bilaterally with cannulae in the lateral cerebral ventricle, substantia nigra, and anterior to the rostral margin of the substantia nigra. Microinjections of the GABA(A) agonist muscimol into each of these areas augmented the stress response evoked by moderate tail pinch. Although consistent changes in the amount of food eaten in response to stress were not observed, stress-evoked gnawing was significantly increased by muscimol at all three sites. Additionally, intraventricular muscimol resulted in an enhancement of stress-evoked oral stereotypy, revolution (escape behavior), and vocalization. The data suggest that a GABAergic component exists in the central mediation of stress. The results are discussed in regard to possible interactions between GABA and central dopamine systems.
M F Hawkins, and
A A Baumeister, and
R H Larue, and
L T Fountain, and
R W Highsmith, and
S K Jeffries, and
M A Duke
March 1982,
Behavioral and neural biology,
M F Hawkins, and
A A Baumeister, and
R H Larue, and
L T Fountain, and
R W Highsmith, and
S K Jeffries, and
M A Duke
January 1993,
Brain research,
M F Hawkins, and
A A Baumeister, and
R H Larue, and
L T Fountain, and
R W Highsmith, and
S K Jeffries, and
M A Duke
June 1982,
Physiology & behavior,
M F Hawkins, and
A A Baumeister, and
R H Larue, and
L T Fountain, and
R W Highsmith, and
S K Jeffries, and
M A Duke
March 1982,
Physiology & behavior,
M F Hawkins, and
A A Baumeister, and
R H Larue, and
L T Fountain, and
R W Highsmith, and
S K Jeffries, and
M A Duke
March 1982,
Life sciences,
M F Hawkins, and
A A Baumeister, and
R H Larue, and
L T Fountain, and
R W Highsmith, and
S K Jeffries, and
M A Duke
January 1979,
Physiology & behavior,
M F Hawkins, and
A A Baumeister, and
R H Larue, and
L T Fountain, and
R W Highsmith, and
S K Jeffries, and
M A Duke
October 1987,
Appetite,
M F Hawkins, and
A A Baumeister, and
R H Larue, and
L T Fountain, and
R W Highsmith, and
S K Jeffries, and
M A Duke
May 1998,
Pharmacology, biochemistry, and behavior,
M F Hawkins, and
A A Baumeister, and
R H Larue, and
L T Fountain, and
R W Highsmith, and
S K Jeffries, and
M A Duke
May 1985,
Physiology & behavior,
M F Hawkins, and
A A Baumeister, and
R H Larue, and
L T Fountain, and
R W Highsmith, and
S K Jeffries, and
M A Duke
July 1996,
Physiology & behavior,
