[Relation between calendar duration of pregnancy and metabolic control of diabetes among pregnant diabetic women]. 1999

M Krzyczkowska-Sendrakowska
Oddziału Patologii Ciazy i Intensywnego Nadzoru Połozniczego Katedry, Połoznictwa Collegium Medicum UJ w Krakowie.

OBJECTIVE In last few years we observe, among diabetic pregnant women, much better metabolic control. At the same time the duration of pregnancy is extended, while number of premature birth is lower and consequently there are less prematurity. METHODS To establish relation between calendar duration of pregnancy and metabolic control among pregnant diabetic women. METHODS The group consisted of 489 diabetic pregnant women. The diabetic control was evaluated by calculating average daily glycemia, maximal average daily glycemia in a trimester, Schlichtkrul's factor, J indicator and average fast glucose level. We have analyzed connection between metabolic control of diabetes and calendar duration of pregnancy in consecutive years of investigation and also within diabetes class of White and Hare. RESULTS The diabetes control among women giving birth within the biological norm was satisfactory. We have shown strong connection between frequency of premature birth and bad diabetic control within all analyzed factors during second and third trimester of pregnancy. The longest average duration of pregnancy in women with diabetes within the White classes, was 40 weeks in G/A class and the shortest 36 weeks in classes R, F, RF. Within the Hare classes the longest duration of pregnancy is 39.1 weeks in GDM class and the shortest 37.9 weeks is in DM+ class. The premature birth frequency was highest in years 1987 and 1988 when the metabolic control of diabetes was not satisfactory and during following years it was between 7 and 19%. In the White classes the lowest frequency of premature birth was in group G/A: 6.6% and the highest in classes R, F, RF: 57.1%. Within other classes that parameter stays at the level 14-19% and in Hare's groups: 10.7% in GDM, 12.3% in DM and 28.6% in DM+. We observe the best metabolic control in class G/A and GDM and the poorest in the R, F, RF and DM+ classes. There is a proven strong correlation between diabetic control and duration of pregnancy in White and Hare groups, until the second trimester in classes G/B and GDM and correlation reaching the third trimester in classes R, F, RF and DM+. Within classes B and D this correlation was not so strong. CONCLUSIONS There is a strong, proven statistical correlation (< 0.01) of all analyzed factors, which reaches second trimester between the metabolic control of diabetes and premature birth. Within the diabetes classes GDM, G/B, R, F, RF and also DM+, there is proven negative statistical correlation between the metabolic control of diabetes and duration of pregnancy.

UI MeSH Term Description Entries
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011248 Pregnancy Complications Conditions or pathological processes associated with pregnancy. They can occur during or after pregnancy, and range from minor discomforts to serious diseases that require medical interventions. They include diseases in pregnant females, and pregnancies in females with diseases. Adverse Birth Outcomes,Complications, Pregnancy,Adverse Birth Outcome,Birth Outcome, Adverse,Complication, Pregnancy,Outcome, Adverse Birth,Pregnancy Complication
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D016640 Diabetes, Gestational Diabetes mellitus induced by PREGNANCY but resolved at the end of pregnancy. It does not include previously diagnosed diabetics who become pregnant (PREGNANCY IN DIABETICS). Gestational diabetes usually develops in late pregnancy when insulin antagonistic hormones peaks leading to INSULIN RESISTANCE; GLUCOSE INTOLERANCE; and HYPERGLYCEMIA. Diabetes Mellitus, Gestational,Diabetes, Pregnancy-Induced,Gestational Diabetes,Diabetes, Pregnancy Induced,Gestational Diabetes Mellitus,Pregnancy-Induced Diabetes

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