Kaposi's sarcoma following malignant mesothelioma. 1999

V Ascoli, and C C Scalzo, and M Andreoni, and L Manente, and A Pistilli, and F Lo Coco
Department of Experimental Medicine and Pathology, University La Sapienza, Rome, Italy. nardi@axrma.uniroma1.it

We report the unusual occurrence of Kaposi's sarcoma following asbestos-related malignant mesothelioma, in a human deficiency virus (HIV)-negative Italian man. Seropositivity to human herpes virus 8 (HHV8) was documented at the time of mesothelioma diagnosis and preceded the onset of Kaposi' sarcoma with a time lapse of 13 months. HHV8 DNA was detected by polymerase chain reaction in lesional Kaposi's sarcoma but not within mesothelioma. By immunostaining, mesothelioma cells expressed interleukin-6 and platelet-derived growth factor, which are important for survival of Kaposi's sarcoma cells. Besides the possibility of a casual association, we hypothesize that mesothelioma-linked factors may have contributed to the development of Kaposi's sarcoma in the presence of HHV8 infection.

UI MeSH Term Description Entries
D008297 Male Males
D008654 Mesothelioma A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed) Mesotheliomas
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010982 Platelet-Derived Growth Factor Mitogenic peptide growth hormone carried in the alpha-granules of platelets. It is released when platelets adhere to traumatized tissues. Connective tissue cells near the traumatized region respond by initiating the process of replication. Platelet Derived Growth Factor,Factor, Platelet-Derived Growth,Growth Factor, Platelet-Derived
D010997 Pleural Neoplasms Neoplasms of the thin serous membrane that envelopes the lungs and lines the thoracic cavity. Pleural neoplasms are exceedingly rare and are usually not diagnosed until they are advanced because in the early stages they produce no symptoms. Neoplasms, Pleural,Neoplasm, Pleural,Pleural Neoplasm
D004273 DNA, Neoplasm DNA present in neoplastic tissue. Neoplasm DNA
D004279 DNA, Viral Deoxyribonucleic acid that makes up the genetic material of viruses. Viral DNA
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000914 Antibodies, Viral Immunoglobulins produced in response to VIRAL ANTIGENS. Viral Antibodies
D000956 Antigens, Viral Substances elaborated by viruses that have antigenic activity. Viral Antigen,Viral Antigens,Antigen, Viral

Related Publications

V Ascoli, and C C Scalzo, and M Andreoni, and L Manente, and A Pistilli, and F Lo Coco
June 1968, The American journal of medicine,
V Ascoli, and C C Scalzo, and M Andreoni, and L Manente, and A Pistilli, and F Lo Coco
February 2008, International journal of STD & AIDS,
V Ascoli, and C C Scalzo, and M Andreoni, and L Manente, and A Pistilli, and F Lo Coco
January 1971, East African medical journal,
V Ascoli, and C C Scalzo, and M Andreoni, and L Manente, and A Pistilli, and F Lo Coco
June 1992, International journal of dermatology,
V Ascoli, and C C Scalzo, and M Andreoni, and L Manente, and A Pistilli, and F Lo Coco
September 1992, Harefuah,
V Ascoli, and C C Scalzo, and M Andreoni, and L Manente, and A Pistilli, and F Lo Coco
October 1987, The American journal of the medical sciences,
V Ascoli, and C C Scalzo, and M Andreoni, and L Manente, and A Pistilli, and F Lo Coco
April 1955, Annals of internal medicine,
V Ascoli, and C C Scalzo, and M Andreoni, and L Manente, and A Pistilli, and F Lo Coco
June 1988, European journal of cancer & clinical oncology,
V Ascoli, and C C Scalzo, and M Andreoni, and L Manente, and A Pistilli, and F Lo Coco
January 1984, Virchows Archiv. A, Pathological anatomy and histopathology,
V Ascoli, and C C Scalzo, and M Andreoni, and L Manente, and A Pistilli, and F Lo Coco
October 1986, Nihon rinsho. Japanese journal of clinical medicine,
Copied contents to your clipboard!