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We have investigated the estrogen-mediated induction of vitellogenin synthesis in rooster liver. We compared the concentrations of vitellogenin messenger RNA (mRNA) in the liver with the concentrations of vitellogenin in the sera of roosters that had recieved various treatments with estrogen. We found no vitellogenin mRNA in the livers of the unstimulated roosters. An initial injection of estrogen was attended by de novo synthesis of vitellogenin mRNA in the liver and accumulation of vitellogenin in the serum. When vitellogenin was no longer present in the serum or liver (the "post-estrogen-serum-negative" state), the liver was found to contain appreciable amounts of vitellogenin mRNA. This mRNA was of the same size as that found in the liver of the rooster actively synthesizing vitellogenin in response to estrogen. Whereas vitellogenin mRNA was in large polysomes in the livers of the roosters actively synthesizing vitellogenin, the vitellogenin mRNA in the liver of the post-estrogen-serum-negative rooster was not associated with polysomes. The possible relevance of these findings to the fact that the rooster responds differently to a primary stimulation with estrogen than to subsequent stimulations is discussed.
K P Mullinix, and
W Wetekam, and
R G Deeley, and
J I Gordon, and
M Meyers, and
K A Kent, and
R F Goldberger
April 1985,
Journal of steroid biochemistry,
K P Mullinix, and
W Wetekam, and
R G Deeley, and
J I Gordon, and
M Meyers, and
K A Kent, and
R F Goldberger
December 1978,
Proceedings of the National Academy of Sciences of the United States of America,
K P Mullinix, and
W Wetekam, and
R G Deeley, and
J I Gordon, and
M Meyers, and
K A Kent, and
R F Goldberger
April 1983,
Biochemical and biophysical research communications,
K P Mullinix, and
W Wetekam, and
R G Deeley, and
J I Gordon, and
M Meyers, and
K A Kent, and
R F Goldberger
February 1985,
Molecular and cellular endocrinology,
K P Mullinix, and
W Wetekam, and
R G Deeley, and
J I Gordon, and
M Meyers, and
K A Kent, and
R F Goldberger
November 1977,
The Journal of biological chemistry,
K P Mullinix, and
W Wetekam, and
R G Deeley, and
J I Gordon, and
M Meyers, and
K A Kent, and
R F Goldberger
January 1978,
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry,
K P Mullinix, and
W Wetekam, and
R G Deeley, and
J I Gordon, and
M Meyers, and
K A Kent, and
R F Goldberger
January 1976,
Molecular and cellular endocrinology,
K P Mullinix, and
W Wetekam, and
R G Deeley, and
J I Gordon, and
M Meyers, and
K A Kent, and
R F Goldberger
March 1991,
Molecular and cellular endocrinology,
K P Mullinix, and
W Wetekam, and
R G Deeley, and
J I Gordon, and
M Meyers, and
K A Kent, and
R F Goldberger
August 1978,
European journal of biochemistry,
K P Mullinix, and
W Wetekam, and
R G Deeley, and
J I Gordon, and
M Meyers, and
K A Kent, and
R F Goldberger
January 1979,
Differentiation; research in biological diversity,
