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The insulin response to oral glucose ingestion was measured in six patients with the Zollinger-Ellison (ZE) syndrome, five patients with partial gastrectomy (antrectomy for duodenal ulcer) and six matched normal subjects. The blood glucose curves were similar in ZE-patients and gastrectomized controls and significantly above the glucose concentrations in normal controls. The insulin response was three-doubled in ZE-patients, whereas gastrectomized controls only doubled their response in comparison with the normal subjects. Treatment of a hepatic gastrinoma by streptozotocin infusion into the hepatic artery in a patient with diabetes mellitus and hyperinsulinism almost normalized his glucose tolerance and insulin secretion. The results demonstrate that the ZE-syndrome is associated with increased insulin release. We suggest that the hyperinsulinism partly is a consequence of previous gastric surgery and partly due to the insulinogenic effect of gastrin.
J F Rehfeld, and
K B Lauritsen, and
F Stadil
September 1972,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
J F Rehfeld, and
K B Lauritsen, and
F Stadil
April 1959,
Lancet (London, England),
J F Rehfeld, and
K B Lauritsen, and
F Stadil
January 1984,
Panminerva medica,
J F Rehfeld, and
K B Lauritsen, and
F Stadil
August 1968,
Klinische Wochenschrift,
J F Rehfeld, and
K B Lauritsen, and
F Stadil
February 1977,
The Journal of clinical investigation,
J F Rehfeld, and
K B Lauritsen, and
F Stadil
September 1970,
Archives of surgery (Chicago, Ill. : 1960),
J F Rehfeld, and
K B Lauritsen, and
F Stadil
November 1974,
Journal of the Iowa Medical Society,
J F Rehfeld, and
K B Lauritsen, and
F Stadil
October 1982,
Journal of the Medical Association of the State of Alabama,
J F Rehfeld, and
K B Lauritsen, and
F Stadil
January 1975,
Voprosy onkologii,
J F Rehfeld, and
K B Lauritsen, and
F Stadil
January 1994,
Klinicheskaia meditsina,
